OBJECTIVE: To analyze the associations of HLA-DRB1* and DQB1* Class II alleles in patients with bilateral Méniére's disease (MD). PATIENTS AND METHODS: Eighty patients from two ethnically defined groups with definite bilateral MD, according to the diagnostic scale of the American Academy of Otolaryngology-Head and Neck Surgery, were compared with normal controls from the same origin in a prospective multicenter study. We performed an allele-specific amplification for HLA-DRB1* and DQB1* genes of the major histocompatibility complex. RESULTS: The allele HLA-DRB1*1101 was associated with bilateral MD in the Mediterranean population (odds ratio, 3.65 [95% confidence intervals, 1.5-9.1], corrected p = 0.029); however, this allele was not associated in the group from Galicia (northwest of Spain). No differences were found in the distribution of alleles for the gene HLA-DQB1* between patients and controls. CONCLUSION: The allele HLA-DRB1*1101 and the allelic group HLA-DRB1*11 may determine an increased susceptibility to develop bilateral MD in a southern European population.
OBJECTIVE: To analyze the associations of HLA-DRB1* and DQB1* Class II alleles in patients with bilateral Méniére's disease (MD). PATIENTS AND METHODS: Eighty patients from two ethnically defined groups with definite bilateral MD, according to the diagnostic scale of the American Academy of Otolaryngology-Head and Neck Surgery, were compared with normal controls from the same origin in a prospective multicenter study. We performed an allele-specific amplification for HLA-DRB1* and DQB1* genes of the major histocompatibility complex. RESULTS: The allele HLA-DRB1*1101 was associated with bilateral MD in the Mediterranean population (odds ratio, 3.65 [95% confidence intervals, 1.5-9.1], corrected p = 0.029); however, this allele was not associated in the group from Galicia (northwest of Spain). No differences were found in the distribution of alleles for the gene HLA-DQB1* between patients and controls. CONCLUSION: The allele HLA-DRB1*1101 and the allelic group HLA-DRB1*11 may determine an increased susceptibility to develop bilateral MD in a southern European population.
Authors: Teresa Requena; Irene Gazquez; Antonia Moreno; Angel Batuecas; Ismael Aran; Andres Soto-Varela; Sofia Santos-Perez; Nicolas Perez; Herminio Perez-Garrigues; Alicia Lopez-Nevot; Eduardo Martin; Ricardo Sanz; Paz Perez; Gabriel Trinidad; Marta E Alarcon-Riquelme; Roberto Teggi; Laura Zagato; Miguel A Lopez-Nevot; Jose A Lopez-Escamez Journal: Immunogenetics Date: 2013-02-01 Impact factor: 2.846
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Authors: José A Lopez-Escamez; Pablo Saenz-Lopez; Irene Gazquez; Antonia Moreno; Carlos Gonzalez-Oller; Andrés Soto-Varela; Sofía Santos; Ismael Aran; Herminio Perez-Garrigues; Agueda Ibañez; Miguel A Lopez-Nevot Journal: BMC Med Genet Date: 2011-01-05 Impact factor: 2.103
Authors: Irene Gazquez; Andres Soto-Varela; Ismael Aran; Sofia Santos; Angel Batuecas; Gabriel Trinidad; Herminio Perez-Garrigues; Carlos Gonzalez-Oller; Lourdes Acosta; Jose A Lopez-Escamez Journal: PLoS One Date: 2011-10-28 Impact factor: 3.240
Authors: Sonia Cabrera; Elena Sanchez; Teresa Requena; Manuel Martinez-Bueno; Jesus Benitez; Nicolas Perez; Gabriel Trinidad; Andrés Soto-Varela; Sofía Santos-Perez; Eduardo Martin-Sanz; Jesus Fraile; Paz Perez; Marta E Alarcon-Riquelme; Angel Batuecas; Juan M Espinosa-Sanchez; Ismael Aran; Jose A Lopez-Escamez Journal: PLoS One Date: 2014-11-14 Impact factor: 3.240