BACKGROUND: Indocyanine green (ICG) is a fluorescent marker that is excited by rays at a wavelength of 768 nm to emit fluorescence at a wavelength of 807 nm in the infrared (IR) range. We developed an IR fluorescence endoscope (IRFE) to observe superficial gastric tumors and assessed its clinical usefulness. OBJECTIVE: To evaluate the clinical usefulness of an IRFE for the assessment of superficial gastric tumors. DESIGN: An observational study. SETTING: University hospital. INTERVENTIONS: Newly developed IRFE. PATIENTS: Thirty patients with gastric tumors were enrolled in this study, and their lesions were subjected to endoscopic submucosal dissection (ESD), or laparoscopic gastrectomy after observation with the IRFE. METHODS: Gastric lesions were subjected to conventional observation, followed by IR fluorescence observation before and after intravenous ICG (0.01 mg/kg) injection. MAIN OUTCOME MEASUREMENTS: The relationship between the positive fluorescence and invasivity of each tumor. RESULTS: Fluorescence was positive in 8 of 10 gastric cancers with submucosal invasion (80%) and 1 of 20 adenomas or intramucosal gastric cancers (5%); the difference was statistically significant (P<.01). CONCLUSION: IRFE is a useful diagnostic tool for estimating the invasivity of gastric tumors.
BACKGROUND:Indocyanine green (ICG) is a fluorescent marker that is excited by rays at a wavelength of 768 nm to emit fluorescence at a wavelength of 807 nm in the infrared (IR) range. We developed an IR fluorescence endoscope (IRFE) to observe superficial gastric tumors and assessed its clinical usefulness. OBJECTIVE: To evaluate the clinical usefulness of an IRFE for the assessment of superficial gastric tumors. DESIGN: An observational study. SETTING: University hospital. INTERVENTIONS: Newly developed IRFE. PATIENTS: Thirty patients with gastric tumors were enrolled in this study, and their lesions were subjected to endoscopic submucosal dissection (ESD), or laparoscopic gastrectomy after observation with the IRFE. METHODS: Gastric lesions were subjected to conventional observation, followed by IR fluorescence observation before and after intravenous ICG (0.01 mg/kg) injection. MAIN OUTCOME MEASUREMENTS: The relationship between the positive fluorescence and invasivity of each tumor. RESULTS: Fluorescence was positive in 8 of 10 gastric cancers with submucosal invasion (80%) and 1 of 20 adenomas or intramucosal gastric cancers (5%); the difference was statistically significant (P<.01). CONCLUSION: IRFE is a useful diagnostic tool for estimating the invasivity of gastric tumors.
Authors: Boudewijn E Schaafsma; J Sven D Mieog; Merlijn Hutteman; Joost R van der Vorst; Peter J K Kuppen; Clemens W G M Löwik; John V Frangioni; Cornelis J H van de Velde; Alexander L Vahrmeijer Journal: J Surg Oncol Date: 2011-04-14 Impact factor: 3.454
Authors: Rob A Vergeer; Robin E P Theunissen; Theodora van Elk; Iris Schmidt; Mark R Postma; Katalin Tamasi; J Marc C van Dijk; Jos M A Kuijlen Journal: Rev Endocr Metab Disord Date: 2022-03-28 Impact factor: 9.306
Authors: Quirijn R J G Tummers; Charlotte E S Hoogstins; Alexander A W Peters; Cor D de Kroon; J Baptist M Z Trimbos; Cornelis J H van de Velde; John V Frangioni; Alexander L Vahrmeijer; Katja N Gaarenstroom Journal: PLoS One Date: 2015-06-25 Impact factor: 3.240