Literature DB >> 17591144

Unsuspected colchicine overdose in a female patient presenting as an acute abdomen.

R E Blackham1, M Little, S Baker, B M Augustson, G C MacQuillan.   

Abstract

We report a case of multi-system organ failure as a result of unsuspected colchicine overdose in a patient with known gout and bulimia nervosa. The patient had initially presented with mild gastrointestinal symptoms with rapid progression to fulminant hepatic failure and multiple organ dysfunction before the causative agent was identified. The patient survived with aggressive intensive care support and ongoing medical treatment. Physicians should be aware of the risk assessment based on the ingested dose, that the clinical presentation of colchicine in toxic doses may be nonspecific with high potential for severe morbidity or death and that survival may occur despite multiple organ failure requinng aggressive support.

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Year:  2007        PMID: 17591144     DOI: 10.1177/0310057X0703500322

Source DB:  PubMed          Journal:  Anaesth Intensive Care        ISSN: 0310-057X            Impact factor:   1.669


  3 in total

1.  Colchicine overdose: A South African experience, a case report.

Authors:  Jenna Essame; Saul Grossberg; Adam Mahomed
Journal:  Afr J Emerg Med       Date:  2020-02-05

2.  Exploring the mechanism of action of dapansutrile in the treatment of gouty arthritis based on molecular docking and molecular dynamics.

Authors:  Jun-Feng Cao; Mei Wu; Shengyan Chen; Hengxiang Xu; Yunli Gong; Lixin Zhang; Qilan Zhang; Xiao Zhang
Journal:  Front Physiol       Date:  2022-08-29       Impact factor: 4.755

3.  Emergency abdominal surgery and colchicine overdose.

Authors:  Andrzej L Komorowski; Jr Martin-Hidalgo Rodil
Journal:  J Emerg Trauma Shock       Date:  2012-10
  3 in total

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