BACKGROUND/AIMS: We evaluated the effectiveness of radiofrequency (RF) ablation combined with transarterial embolization using Lipiodol and gelatin sponge. METHODOLOGY: A total of 18 normal pig liver lobes were randomly assigned to the following three different RF ablation groups, 1) combined with TAE using Lipiodol and gelatin sponge as "LpTAE group"; 2) combined with TAE using gelatin sponge only as "TAE group"; 3) ablation alone as "control group". Ablations were performed under open laparotomy using an RF generator and a 2-cm expandable needle. The diameter of coagulation and the ablation time were compared among the three groups. RESULTS: The characteristic shape of coagulated area differed among the three groups. The long-axis diameter showed no significant difference among the three groups (27.5mm, 27.5mm, 26.7mm; respectively), while the short-axis diameter was significantly larger in the LpTAE group compared with the control groups (25.2mm vs. 20.5mm; p < 0.05). The total ablation time was significantly shorter in the LpTAE and TAE groups compared with the control group (166, 204 seconds vs. 309 seconds; p = 0.001, p = 0.01). CONCLUSIONS: RF ablation combined with LpTAE produced larger and more spherical areas of coagulation in a shorter ablation time. Such an advantage could potentially enhance the clinical effectiveness of RF ablation.
BACKGROUND/AIMS: We evaluated the effectiveness of radiofrequency (RF) ablation combined with transarterial embolization using Lipiodol and gelatin sponge. METHODOLOGY: A total of 18 normal pig liver lobes were randomly assigned to the following three different RF ablation groups, 1) combined with TAE using Lipiodol and gelatin sponge as "LpTAE group"; 2) combined with TAE using gelatin sponge only as "TAE group"; 3) ablation alone as "control group". Ablations were performed under open laparotomy using an RF generator and a 2-cm expandable needle. The diameter of coagulation and the ablation time were compared among the three groups. RESULTS: The characteristic shape of coagulated area differed among the three groups. The long-axis diameter showed no significant difference among the three groups (27.5mm, 27.5mm, 26.7mm; respectively), while the short-axis diameter was significantly larger in the LpTAE group compared with the control groups (25.2mm vs. 20.5mm; p < 0.05). The total ablation time was significantly shorter in the LpTAE and TAE groups compared with the control group (166, 204 seconds vs. 309 seconds; p = 0.001, p = 0.01). CONCLUSIONS: RF ablation combined with LpTAE produced larger and more spherical areas of coagulation in a shorter ablation time. Such an advantage could potentially enhance the clinical effectiveness of RF ablation.
Authors: Christoph Reissfelder; Nuh N Rahbari; L Urrutia Bejarano; Thomas Schmidt; Nikolas Kortes; Hans-Ulrich Kauczor; Markus W Büchler; Jürgen Weitz; Moritz Koch Journal: Langenbecks Arch Surg Date: 2014-03-11 Impact factor: 3.445