Literature DB >> 17590532

New sphingolipids from the root of Isatis indigotica and their cytotoxic activity.

Xiang Li1, Dong-Dong Sun, Jian-Wei Chen, Li-Wei He, Han-Qing Zhang, Hui-Qin Xu.   

Abstract

Two new sphingolipids were isolated from the 95% EtOH extract of traditional Chinese medicinal plant Isatis indigotica. Their structures were elucidated as (2S,3R)-3-hydroxymethyl-N-(2'-hydroxynonacosanoyl)-trideca-9E-sphingenine(1) and 1-O-beta-D-glucopyranosyl-(2S,3R)-3-hydroxymethyl-N-(2'-hydroxynonacosanoyl)-trideca-9E-sphingenine(2) on the basis of spectroscopic data. Their cytotoxic effects were evaluated by using MTT method.

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Year:  2007        PMID: 17590532     DOI: 10.1016/j.fitote.2007.03.017

Source DB:  PubMed          Journal:  Fitoterapia        ISSN: 0367-326X            Impact factor:   2.882


  3 in total

1.  Two novel ceramides with a phytosphingolipid and a tertiary amide structure from Zephyranthes candida.

Authors:  Zhi-Ping Wu; Yu Chen; Bing Xia; Ming Wang; Yun-Fa Dong; Xu Feng
Journal:  Lipids       Date:  2008-10-22       Impact factor: 1.880

2.  Synthesis, NMR characterization and divergent biological actions of 2'-hydroxy-ceramide/dihydroceramide stereoisomers in MCF7 cells.

Authors:  Zdzislaw M Szulc; Aiping Bai; Jacek Bielawski; Nalini Mayroo; Doreen E Miller; Hanna Gracz; Yusuf A Hannun; Alicja Bielawska
Journal:  Bioorg Med Chem       Date:  2010-09-28       Impact factor: 3.641

3.  Microscopic Mass Spectrometry Imaging Reveals the Distribution of Phytochemicals in the Dried Root of Isatis tinctoria.

Authors:  Li-Xing Nie; Jing Dong; Lie-Yan Huang; Xiu-Yu Qian; Chao-Jie Lian; Shuai Kang; Zhong Dai; Shuang-Cheng Ma
Journal:  Front Pharmacol       Date:  2021-06-29       Impact factor: 5.810

  3 in total

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