| Literature DB >> 17590342 |
I S Marcos1, M A Escola, R F Moro, P Basabe, D Diez, F Sanz, F Mollinedo, J de la Iglesia-Vicente, B G Sierra, J G Urones.
Abstract
Several sesterterpenolides analogues of dysidiolide have been synthesized and their in vitro antitumoural activity against human HeLa, A549, HT-29 and HL-60 carcinoma cells is presented. The proliferation inhibition data showed a significant antitumour activity of the compounds 1b, 2a, 2b, 3a, 3b, 4a, 4b, 5, inhibiting proliferation of distinct cancer cell types with an IC(50) in the low micromolar range.Entities:
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Year: 2007 PMID： 17590342 DOI： 10.1016/j.bmc.2007.06.007
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641