| Literature DB >> 17588900 |
Tiago Fleming Outeiro1, Eirene Kontopoulos, Stephen M Altmann, Irina Kufareva, Katherine E Strathearn, Allison M Amore, Catherine B Volk, Michele M Maxwell, Jean-Christophe Rochet, Pamela J McLean, Anne B Young, Ruben Abagyan, Mel B Feany, Bradley T Hyman, Aleksey G Kazantsev.
Abstract
The sirtuins are members of the histone deacetylase family of proteins that participate in a variety of cellular functions and play a role in aging. We identified a potent inhibitor of sirtuin 2 (SIRT2) and found that inhibition of SIRT2 rescued alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. Genetic inhibition of SIRT2 via small interfering RNA similarly rescued alpha-synuclein toxicity. Furthermore, the inhibitors protected against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease. The results suggest a link between neurodegeneration and aging.Entities:
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Year: 2007 PMID： 17588900 DOI： 10.1126/science.1143780
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728