| Literature DB >> 17588142 |
P L Rekha1, Vijayalakshmi Valluri, Shilpa S Rakh, Vinod Pantula, M Ishaq.
Abstract
The present study was designed to analyze the distribution of HLA DQ B1* and DR B1* in patients with goitrous juvenile autoimmune hypothyroidism from Hyderabad, India. Analysis indicated an increase in the frequencies of HLA DQ B1* 03 allele (P < 0.000) and HLA DR B1* 04 (P < 0.05) alleles in this group of patients when compared to the controls, whereas the frequency of DQB1* 05 was found to be decreased in patients' group compared to the controls (p < 0.01). To conclude, we report a positive correlation between DQ B1* 03 and DR B1* 04 and goitrous juvenile autoimmune hypothyroidism, whereas DQB1* 05 is observed to be negatively correlated with this thyroid dysfunction. Since the disease-susceptible HLA class II alleles appear to differ in various ethnic groups for some autoimmune diseases, the observed association from Indian series of patients holds significance.Entities:
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Year: 2007 PMID： 17588142 DOI： 10.1007/s10875-007-9102-2
Source DB: PubMed Journal: J Clin Immunol ISSN： 0271-9142 Impact factor: 8.317