Literature DB >> 17587816

Epithelial-mesenchymal transition in prostate cancer and the potential role of kallikrein serine proteases.

Mitchell G Lawrence1, Tara L Veveris-Lowe, Astrid K Whitbread, David L Nicol, Judith A Clements.   

Abstract

Prostate cancer is associated with significant mortality once the tumour has spread outside the gland. Epithelial-mesenchymal transition (EMT) has been proposed to facilitate this dissemination of tumour cells. In this article we summarize the evidence for EMT in prostate cancer, drawing on the expression of EMT-related markers and the functions of factors known to induce EMT in other systems. We also discuss our recent findings that two members of the tissue kallikrein family of serine proteases, prostate-specific antigen (PSA/KLK3) and kallikrein-related peptidase 4 (KLK4), lead to EMT-like changes in PC3 prostate cancer cells. 2007 S. Karger AG, Basel

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Year:  2007        PMID： 17587816     DOI： 10.1159/000101311

Source DB:  PubMed          Journal:  Cells Tissues Organs        ISSN： 1422-6405            Impact factor:   2.481


  13 in total

1.  Phorbol ester phorbol-12-myristate-13-acetate induces epithelial to mesenchymal transition in human prostate cancer ARCaPE cells.

Authors:  Hui He; Alec J Davidson; Daqing Wu; Fray F Marshall; Leland W K Chung; Haiyen E Zhau; Dalin He; Ruoxiang Wang
Journal:  Prostate       Date:  2010-07-01       Impact factor: 4.104

2.  Illuminating radiogenomic characteristics of glioblastoma multiforme through integration of MR imaging, messenger RNA expression, and DNA copy number variation.

Authors:  Neema Jamshidi; Maximilian Diehn; Markus Bredel; Michael D Kuo
Journal:  Radiology       Date:  2013-10-28       Impact factor: 11.105

Review 3.  Tetraspanins as regulators of the tumour microenvironment: implications for metastasis and therapeutic strategies.

Authors:  S Detchokul; E D Williams; M W Parker; A G Frauman
Journal:  Br J Pharmacol       Date:  2014-12       Impact factor: 8.739

4.  Androgen regulation of epithelial-mesenchymal transition in prostate tumorigenesis.

Authors:  Emily A Matuszak; Natasha Kyprianou
Journal:  Expert Rev Endocrinol Metab       Date:  2011-05

5.  Molecular pathways involved in prostate carcinogenesis: insights from public microarray datasets.

Authors:  Sarah C Baetke; Michiel E Adriaens; Renaud Seigneuric; Chris T Evelo; Lars M T Eijssen
Journal:  PLoS One       Date:  2012-11-20       Impact factor: 3.240

Review 6.  Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs).

Authors:  Peter Goettig; Viktor Magdolen; Hans Brandstetter
Journal:  Biochimie       Date:  2010-07-06       Impact factor: 4.079

7.  A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survival.

Authors:  Jyotsna Batra; Christina M Nagle; Tracy O'Mara; Melanie Higgins; Ying Dong; Olivia L Tan; Felicity Lose; Lene Marie Skeie; Srilakshmi Srinivasan; Kelly L Bolton; Honglin Song; Susan J Ramus; Simon A Gayther; Paul D P Pharoah; Mary-Anne Kedda; Amanda B Spurdle; Judith A Clements
Journal:  BMC Cancer       Date:  2011-04-01       Impact factor: 4.430

8.  Enrichment of the Cancer Stem Phenotype in Sphere Cultures of Prostate Cancer Cell Lines Occurs through Activation of Developmental Pathways Mediated by the Transcriptional Regulator ΔNp63α.

Authors:  Roberto Portillo-Lara; Mario Moisés Alvarez
Journal:  PLoS One       Date:  2015-06-25       Impact factor: 3.240

9.  Overexpression of myosin VI in prostate cancer cells enhances PSA and VEGF secretion, but has no effect on endocytosis.

Authors:  C Puri; M V Chibalina; S D Arden; A J Kruppa; J Kendrick-Jones; F Buss
Journal:  Oncogene       Date:  2009-10-26       Impact factor: 9.867

Review 10.  Molecular and pathological signatures of epithelial-mesenchymal transitions at the cancer invasion front.

Authors:  Olivier De Wever; Patrick Pauwels; Bram De Craene; Michèle Sabbah; Shahin Emami; Gérard Redeuilh; Christian Gespach; Marc Bracke; Geert Berx
Journal:  Histochem Cell Biol       Date:  2008-07-22       Impact factor: 4.304
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