Literature DB >> 17587570

Potent and selective CC-chemokine receptor-2 (CCR2) antagonists as a potential treatment for asthma.

Bharat Lagu1, Chrissy Gerchak, Meng Pan, Cuifen Hou, Monica Singer, Ravi Malaviya, Michele Matheis, Gil Olini, Druie Cavender, Michael Wachter.   

Abstract

A number of compounds bearing a quaternary ammonium moiety were found to be antagonists with nanomolar binding affinity for the chemokine receptor-2. The structure-activity relationships in the series are described herein along with some detailed characterization of the interesting compounds.

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Year:  2007        PMID： 17587570     DOI： 10.1016/j.bmcl.2007.01.115

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

Review 1.  Structural Analysis of Chemokine Receptor-Ligand Interactions.

Authors:  Marta Arimont; Shan-Liang Sun; Rob Leurs; Martine Smit; Iwan J P de Esch; Chris de Graaf
Journal:  J Med Chem       Date:  2017-03-10       Impact factor: 7.446

Review 2.  The multiple faces of CCL13 in immunity and inflammation.

Authors:  E Mendez-Enriquez; E A García-Zepeda
Journal:  Inflammopharmacology       Date:  2013-07-12       Impact factor: 4.473

3.  Inflammatory cytokine and osmolarity changes in the tears of dry eye patients treated with topical 1% methylprednisolone.

Authors:  Ji Hwan Lee; Kyung Min; Se Kyung Kim; Eung Kweon Kim; Tae-im Kim
Journal:  Yonsei Med J       Date:  2014-01       Impact factor: 2.759

4.  Synthesis, 3 H-labelling and in vitro evaluation of a substituted dipiperidine alcohol as a potential ligand for chemokine receptor 2.

Authors:  Markus Artelsmair; Patricia Miranda-Azpiazu; Lee Kingston; Jonas Bergare; Magnus Schou; Andrea Varrone; Charles S Elmore
Journal:  J Labelled Comp Radiopharm       Date:  2019-05-30       Impact factor: 1.921

Review 5.  International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors.

Authors:  Francoise Bachelerie; Adit Ben-Baruch; Amanda M Burkhardt; Christophe Combadiere; Joshua M Farber; Gerard J Graham; Richard Horuk; Alexander Hovard Sparre-Ulrich; Massimo Locati; Andrew D Luster; Alberto Mantovani; Kouji Matsushima; Philip M Murphy; Robert Nibbs; Hisayuki Nomiyama; Christine A Power; Amanda E I Proudfoot; Mette M Rosenkilde; Antal Rot; Silvano Sozzani; Marcus Thelen; Osamu Yoshie; Albert Zlotnik
Journal:  Pharmacol Rev       Date:  2013-11-11       Impact factor: 25.468
  5 in total

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