Literature DB >> 17586488

The UCS factor Steif/Unc-45b interacts with the heat shock protein Hsp90a during myofibrillogenesis.

Christelle Etard1, Martine Behra, Nadine Fischer, David Hutcheson, Robert Geisler, Uwe Strähle.   

Abstract

Contraction of muscles is mediated by highly organized arrays of myosin motor proteins. We report here the characterization of a mutation of a UCS gene named steif/unc-45b that is required for the formation of ordered myofibrils in both the skeletal and cardiac muscles of zebrafish. We show that Steif/Unc-45b interacts with the chaperone Hsp90a in vitro. The two genes are co-expressed in the skeletal musculature and knockdown of Hsp90a leads to impaired myofibril formation in the same manner as lack of Steif/Unc-45b activity. Transcripts of both genes are up-regulated in steif mutants suggesting co-regulation of the two genes. Our data indicate a requirement of Steif/unc-45b and Hsp90a for the assembly of the contractile apparatus in the vertebrate skeletal musculature.

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Year:  2007        PMID： 17586488     DOI： 10.1016/j.ydbio.2007.05.014

Source DB:  PubMed          Journal:  Dev Biol        ISSN： 0012-1606            Impact factor:   3.582


  62 in total

1.  UNC-45/CRO1/She4p (UCS) protein forms elongated dimer and joins two myosin heads near their actin binding region.

Authors:  Hang Shi; Günter Blobel
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-29       Impact factor: 11.205

2.  Drosophila UNC-45 accumulates in embryonic blastoderm and in muscles, and is essential for muscle myosin stability.

Authors:  Chi F Lee; Girish C Melkani; Qin Yu; Jennifer A Suggs; William A Kronert; Yoko Suzuki; Lori Hipolito; Maureen G Price; Henry F Epstein; Sanford I Bernstein
Journal:  J Cell Sci       Date:  2011-02-01       Impact factor: 5.285

Review 3.  The initial steps of myofibril assembly: integrins pave the way.

Authors:  John C Sparrow; Frieder Schöck
Journal:  Nat Rev Mol Cell Biol       Date:  2009-02-04       Impact factor: 94.444

Review 4.  Build it up-Tear it down: protein quality control in the cardiac sarcomere.

Authors:  Monte S Willis; Jonathan C Schisler; Andrea L Portbury; Cam Patterson
Journal:  Cardiovasc Res       Date:  2008-10-29       Impact factor: 10.787

5.  Dual function of the UNC-45b chaperone with myosin and GATA4 in cardiac development.

Authors:  Daisi Chen; Shumin Li; Ram Singh; Sarah Spinette; Reinhard Sedlmeier; Henry F Epstein
Journal:  J Cell Sci       Date:  2012-05-02       Impact factor: 5.285

6.  Pathogenic Variants in the Myosin Chaperone UNC-45B Cause Progressive Myopathy with Eccentric Cores.

Authors:  Sandra Donkervoort; Carl E Kutzner; Ying Hu; Xavière Lornage; John Rendu; Tanya Stojkovic; Jonathan Baets; Sarah B Neuhaus; Jantima Tanboon; Reza Maroofian; Véronique Bolduc; Magdalena Mroczek; Stefan Conijn; Nancy L Kuntz; Ana Töpf; Soledad Monges; Fabiana Lubieniecki; Riley M McCarty; Katherine R Chao; Serena Governali; Johann Böhm; Kanokwan Boonyapisit; Edoardo Malfatti; Tumtip Sangruchi; Iren Horkayne-Szakaly; Carola Hedberg-Oldfors; Stephanie Efthymiou; Satoru Noguchi; Sarah Djeddi; Aritoshi Iida; Gabriella di Rosa; Chiara Fiorillo; Vincenzo Salpietro; Niklas Darin; Julien Fauré; Henry Houlden; Anders Oldfors; Ichizo Nishino; Willem de Ridder; Volker Straub; Wojciech Pokrzywa; Jocelyn Laporte; A Reghan Foley; Norma B Romero; Coen Ottenheijm; Thorsten Hoppe; Carsten G Bönnemann
Journal:  Am J Hum Genet       Date:  2020-11-19       Impact factor: 11.025

7.  Defective glycinergic synaptic transmission in zebrafish motility mutants.

Authors:  Hiromi Hirata; Eloisa Carta; Iori Yamanaka; Robert J Harvey; John Y Kuwada
Journal:  Front Mol Neurosci       Date:  2010-01-08       Impact factor: 5.639

8.  Lack of Apobec2-related proteins causes a dystrophic muscle phenotype in zebrafish embryos.

Authors:  Christelle Etard; Urmas Roostalu; Uwe Strähle
Journal:  J Cell Biol       Date:  2010-05-03       Impact factor: 10.539

9.  Myosin assembly, maintenance and degradation in muscle: Role of the chaperone UNC-45 in myosin thick filament dynamics.

Authors:  Torah M Kachur; David B Pilgrim
Journal:  Int J Mol Sci       Date:  2008-09-19       Impact factor: 6.208

10.  Loss of Smyhc1 or Hsp90alpha1 function results in different effects on myofibril organization in skeletal muscles of zebrafish embryos.

Authors:  Marta Codina; Junling Li; Joaquim Gutiérrez; Joseph P Y Kao; Shao Jun Du
Journal:  PLoS One       Date:  2010-01-01       Impact factor: 3.240
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