Eugenio Pozzati1, Mino Zucchelli2, Mario Schiavina2, Paola Contini2, Maria Pia Foschini2. 1. Division of Neurosurgery and Service of Pathology, Bellaria Hospital and Respiratory Pathophysiology, S. Orsola Policlinic, Bologna 40100, Italy. Electronic address: eugenio.pozzati@ausl.bologna.it. 2. Division of Neurosurgery and Service of Pathology, Bellaria Hospital and Respiratory Pathophysiology, S. Orsola Policlinic, Bologna 40100, Italy.
Abstract
BACKGROUND: Lymphangioleiomyomatosis is a progressive interstitial lung disease that affects young women. It has been suggested that estrogens play a role in its evolution, and progesterone therapy is often provided in these cases. CASE DESCRIPTION: We present a case of a postmenopausal woman with LAM treated with progesterone; subsequently, rapid growth of multiple intracranial meningiomas was observed. One prominent lesion was excised, and 3 other lesions regressed spontaneously over 2 years. CONCLUSIONS: This is a rare case of a non-pregnancy-related regression of meningiomas in a woman affected by LAM. The significance of this association and the hormonal treatment of the disease are discussed.
BACKGROUND:Lymphangioleiomyomatosis is a progressive interstitial lung disease that affects young women. It has been suggested that estrogens play a role in its evolution, and progesterone therapy is often provided in these cases. CASE DESCRIPTION: We present a case of a postmenopausal woman with LAM treated with progesterone; subsequently, rapid growth of multiple intracranial meningiomas was observed. One prominent lesion was excised, and 3 other lesions regressed spontaneously over 2 years. CONCLUSIONS: This is a rare case of a non-pregnancy-related regression of meningiomas in a woman affected by LAM. The significance of this association and the hormonal treatment of the disease are discussed.