Hiroshi Saito1, Kaoru Nomura, Mari Hotta, Kazue Takano. 1. Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan. hiroshisa@endm.twmu.ac.jp
Abstract
OBJECTIVE: The effect of nutritional state on lymphocytes in patients with anorexia nervosa (AN) was studied. METHOD: We studied total lymphocyte count (TLC), lymphocyte subsets, and nutritional markers [body mass index (BMI), insulin-like growth factor-1 (IGF-I)], and serum zinc concentration) in 33 patients with AN and 10 healthy controls. RESULTS: TLC positively correlated with BMI (r = .680, p < .001), IGF-I (r = .609 p < .001), and zinc (r = .589, p < .001). The CD4+ T-lymphocyte (CD4) proportion correlated negatively with BMI (r = -.301, p = .05) and IGF-I (r = -.346, p = .023), counteracting the effect of malnutrition on TLC. However, because this increase in CD4 proportion was weak, patients with very severe malnutrition (indicated by serum zinc less than 40 microg/dL) had critically low CD4 counts of less than 200 cells/microL. CONCLUSION: Our findings suggest that lymphocyte counts and subset proportion change in an opposite manner in patients with AN, and that decrease in serum zinc levels is nutrition-related. (c) 2007 by Wiley Periodicals, Inc.
OBJECTIVE: The effect of nutritional state on lymphocytes in patients with anorexia nervosa (AN) was studied. METHOD: We studied total lymphocyte count (TLC), lymphocyte subsets, and nutritional markers [body mass index (BMI), insulin-like growth factor-1 (IGF-I)], and serum zinc concentration) in 33 patients with AN and 10 healthy controls. RESULTS: TLC positively correlated with BMI (r = .680, p < .001), IGF-I (r = .609 p < .001), and zinc (r = .589, p < .001). The CD4+ T-lymphocyte (CD4) proportion correlated negatively with BMI (r = -.301, p = .05) and IGF-I (r = -.346, p = .023), counteracting the effect of malnutrition on TLC. However, because this increase in CD4 proportion was weak, patients with very severe malnutrition (indicated by serum zinc less than 40 microg/dL) had critically low CD4 counts of less than 200 cells/microL. CONCLUSION: Our findings suggest that lymphocyte counts and subset proportion change in an opposite manner in patients with AN, and that decrease in serum zinc levels is nutrition-related. (c) 2007 by Wiley Periodicals, Inc.
Authors: Marko Lucijanic; Ivo Veletic; Dario Rahelic; Vlatko Pejsa; David Cicic; Marko Skelin; Ana Livun; Katarina Marija Tupek; Tajana Stoos-Veic; Tomo Lucijanic; Ana Maglicic; Rajko Kusec Journal: Wien Klin Wochenschr Date: 2018-01-25 Impact factor: 1.704