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Literature DB >> 17584155

Allosteric enhancers for A1 adenosine receptor.

Pier Giovanni Baraldi¹, Maria Antonietta Iaconinoto, Allan R Moorman, Maria Dora Carrion, Carlota Lopez Cara, Delia Preti, Olga Cruz López, Francesca Fruttarolo, Mojgan Aghazade Tabrizi, Romeo Romagnoli.

Abstract

Allosteric enhancers at the adenosine A(1) receptor have received attention as anti-arrhythmic cardiac agents, and, more recently, as anti-lipolytic agents. In addition, allosteric modulators at the adenosine A(1) receptor have therapeutic potential as analgesics and neuroprotective agents. In particular, the compounds with improved potency as enhancers and reduced antagonist properties are mentioned.

Entities: Disease Gene

Mesh：

Substances：

Year: 2007 PMID： 17584155 DOI： 10.2174/138955707780859459

Source DB: PubMed Journal: Mini Rev Med Chem ISSN： 1389-5575 Impact factor: 3.862

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Cited

9 in total

1. 3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists.

Authors: Luigi Aurelio; Celine Valant; Heidi Figler; Bernard L Flynn; Joel Linden; Patrick M Sexton; Arthur Christopoulos; Peter J Scammells
Journal: Bioorg Med Chem Date: 2009-08-20 Impact factor: 3.641

Review 2. International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors--an update.

Authors: Bertil B Fredholm; Adriaan P IJzerman; Kenneth A Jacobson; Joel Linden; Christa E Müller
Journal: Pharmacol Rev Date: 2011-02-08 Impact factor: 25.468

Allosteric enhancers for A1 adenosine receptor.

1. 3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists.

Review 2. International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors--an update.

Review 3. Adenosine and protection from acute kidney injury.

Review 4. Allosteric modulation of purine and pyrimidine receptors.

5. A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury.

6. IL-11 is required for A1 adenosine receptor-mediated protection against ischemic AKI.

Review 7. Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts.

8. Allosteric modulation of adenosine receptors.

9. Structural Basis for Binding of Allosteric Drug Leads in the Adenosine A₁ Receptor.

Allosteric enhancers for A1 adenosine receptor.

1. 3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists.

Review 2. International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors--an update.

Review 3. Adenosine and protection from acute kidney injury.

Review 4. Allosteric modulation of purine and pyrimidine receptors.

5. A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury.

6. IL-11 is required for A1 adenosine receptor-mediated protection against ischemic AKI.

Review 7. Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts.

8. Allosteric modulation of adenosine receptors.

9. Structural Basis for Binding of Allosteric Drug Leads in the Adenosine A1 Receptor.

9. Structural Basis for Binding of Allosteric Drug Leads in the Adenosine A₁ Receptor.