Literature DB >> 17583698

Distinct roles of TIR and non-TIR regions in the subcellular localization and signaling properties of MyD88.

Tadashi Nishiya1, Emi Kajita, Takahiro Horinouchi, Arata Nishimoto, Soichi Miwa.   

Abstract

MyD88 is a cytoplasmic adaptor protein that is critical for Toll-like receptor (TLR) signaling. The subcellular localization of MyD88 is characterized as large condensed forms in the cytoplasm. The mechanism and significance of this localization with respect to the signaling function, however, are currently unknown. Here, we demonstrate that MyD88 localization depends on the entire non-TIR region and that the correct cellular targeting of MyD88 is indispensable for its signaling function. The Toll-interleukin I receptor-resistance (TIR) domain does not determine the subcellular localization, but it mediates interaction with specific TLRs. These findings reveal distinct roles for the TIR and non-TIR regions in the subcellular localization and signaling properties of MyD88.

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Year:  2007        PMID： 17583698     DOI： 10.1016/j.febslet.2007.06.008

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  21 in total

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2.  Toll/interleukin-1 receptor domain dimers as the platform for activation and enhanced inhibition of Toll-like receptor signaling.

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Journal:  Nat Rev Immunol       Date:  2014-08       Impact factor: 53.106

Review 4.  Deconstructing innate immune signaling in myelodysplastic syndromes.

Authors:  Madeline Niederkorn; Molly Smith; Laura Barreyro; Melinda E Varney; Katelyn Melgar; Daniel T Starczynowski
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5.  Phosphatidylinositol 4-phosphate 5-kinase α facilitates Toll-like receptor 4-mediated microglial inflammation through regulation of the Toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP) location.

Authors:  Tu Thi Ngoc Nguyen; Yong Min Kim; T Doohun Kim; Oanh Thi Tu Le; Jae Jin Kim; Ho Chul Kang; Hiroshi Hasegawa; Yasunori Kanaho; Ilo Jou; Sang Yoon Lee
Journal:  J Biol Chem       Date:  2013-01-07       Impact factor: 5.157

6.  Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins.

Authors:  Tadashi Nishiya; Kazuma Matsumoto; Satoshi Maekawa; Emi Kajita; Takahiro Horinouchi; Masahiro Fujimuro; Kouetsu Ogasawara; Takashi Uehara; Soichi Miwa
Journal:  J Biol Chem       Date:  2011-01-03       Impact factor: 5.157

7.  Regulation of MyD88 aggregation and the MyD88-dependent signaling pathway by sequestosome 1 and histone deacetylase 6.

Authors:  Takeshi Into; Megumi Inomata; Shumpei Niida; Yukitaka Murakami; Ken-ichiro Shibata
Journal:  J Biol Chem       Date:  2010-09-13       Impact factor: 5.157

8.  Natural loss-of-function mutation of myeloid differentiation protein 88 disrupts its ability to form Myddosomes.

Authors:  Kamalpreet Nagpal; Theo S Plantinga; Cherilyn M Sirois; Brian G Monks; Eicke Latz; Mihai G Netea; Douglas T Golenbock
Journal:  J Biol Chem       Date:  2011-02-16       Impact factor: 5.157

9.  Ligand-independent toll-like receptor signals generated by ectopic overexpression of MyD88 generate local and systemic antitumor immunity.

Authors:  Zachary C Hartman; Takuya Osada; Oliver Glass; Xiao Y Yang; Gang-Jun Lei; H Kim Lyerly; Timothy M Clay
Journal:  Cancer Res       Date:  2010-09-07       Impact factor: 12.701

10.  Functional characterization of bovine TIRAP and MyD88 in mediating bacterial lipopolysaccharide-induced endothelial NF-kappaB activation and apoptosis.

Authors:  Elizabeth A Cates; Erin E Connor; David M Mosser; Douglas D Bannerman
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