Literature DB >> 17583500

Aminopyrrolidineamide inhibitors of site-1 protease.

Bruce A Hay1, Barbara Abrams, Allice Y Zumbrunn, James J Valentine, Laurie C Warren, Stephen F Petras, Lorraine D Shelly, Angela Xia, Alison H Varghese, Julie L Hawkins, Jennifer A Van Camp, Michael D Robbins, Katherine Landschulz, H James Harwood.   

Abstract

The discovery and efficacy of a series of potent aminopyrrolidineamide-based inhibitors of sterol regulatory element binding protein site-1 protease is described.

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Year:  2007        PMID: 17583500     DOI: 10.1016/j.bmcl.2007.06.031

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  30 in total

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Review 7.  SCAP/SREBPs are Central Players in Lipid Metabolism and Novel Metabolic Targets in Cancer Therapy.

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Review 10.  Proteolytic Control of Lipid Metabolism.

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