Wei Liu1, Hong-Jie Wang, Nan Si, Bao-Lin Bian. 1. Institute of Chinese Meteria Medica, China Academg of Chinese Medical Sciences, Beijing 100700, China.
Abstract
OBJECTIVE: To determine the optimum technical parameters through controlling the different factors and the content of Dripping Pill. METHOD: Time of dissolution, spherical degree and pill weight as parameters, the influential factors were investigated by orthogonal test and then to determine the content of liensinine, isoliensinine, neferine in plumula nelumbinis Alkaloid Dripping Pill. RESULT: The optimum condition: 75% PEG4000 as matrix, methyl-silicon oil as refrigerant, 4 cm dripping distance, 10 degrees C refrigerant, 30 drippings per minute. CONCLUSION: The good quality pills can be produced through this process and the HPLC determination method is simple, reliable and can be used in the quality control of plumula nelumbinis Alkaloid Dripping Pill.
OBJECTIVE: To determine the optimum technical parameters through controlling the different factors and the content of Dripping Pill. METHOD: Time of dissolution, spherical degree and pill weight as parameters, the influential factors were investigated by orthogonal test and then to determine the content of liensinine, isoliensinine, neferine in plumula nelumbinis Alkaloid Dripping Pill. RESULT: The optimum condition: 75% PEG4000 as matrix, methyl-silicon oil as refrigerant, 4 cm dripping distance, 10 degrees C refrigerant, 30 drippings per minute. CONCLUSION: The good quality pills can be produced through this process and the HPLC determination method is simple, reliable and can be used in the quality control of plumula nelumbinis Alkaloid Dripping Pill.