Literature DB >> 17582512

Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration.

Daniela Rosenkranz1, Sascha Weyer, Eva Tolosa, Alexandra Gaenslen, Daniela Berg, Thomas Leyhe, Thomas Gasser, Lars Stoltze.   

Abstract

The involvement of regulatory T cells (Treg) in autoimmune-disease development has been demonstrated. However, their alteration during ageing and age-related diseases has not been thoroughly investigated yet. Alzheimer (AD) and Parkinson disease (PD), are related to protein-misfolding and are accompanied by neuroinflammation. Since, it has been hypothesized that the neuroinflammation attempts to prevent disease development, we speculated that changes in Treg might affect any relevant immune mechanism. The analysis of Treg from AD and PD patients as well as non-affected individuals, revealed that the frequency of Treg (CD4(+)Foxp3(+)) increases with age and is accompanied by intensified suppressive activity for Treg in patients.

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Year:  2007        PMID： 17582512     DOI： 10.1016/j.jneuroim.2007.05.011

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  90 in total

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