OBJECTIVE: Functional brain abnormalities associated with autism in 3-8-year-old boys were studied with EEG recorded under controlled experimental condition of sustained visual attention and behavioral stillness. METHODS: EEG was recorded in two independent samples of boys with autism (BWA) from Moscow (N=21) and Gothenburg (N=23) and a corresponding number of age-matched typically developing boys (TDB). EEG spectral power (SP) and SP interhemispheric asymmetry within delta, theta and alpha bands were analyzed. RESULTS: BWA comprised a non-homogeneous group in relation to theta and alpha SP. When four outliers were excluded the only between-group difference in absolute SP was a higher amount of prefrontal delta in BWA. BWA of both samples demonstrated atypical leftward broadband EEG asymmetry with a maximum effect over the mid-temporal regions. Concurrently, the normal leftward asymmetry of mu rhythm was absent in BWA. CONCLUSIONS: The abnormal broadband EEG asymmetry in autism may point to a diminished capacity of right temporal cortex to generate EEG rhythms. The concurrent lack of normal leftward asymmetry of mu rhythm suggests that abnormalities in EEG lateralization in autism may be regionally/functionally specific. SIGNIFICANCE: The data provide evidence for abnormal functional brain lateralization in autism.
OBJECTIVE:Functional brain abnormalities associated with autism in 3-8-year-old boys were studied with EEG recorded under controlled experimental condition of sustained visual attention and behavioral stillness. METHODS: EEG was recorded in two independent samples of boys with autism (BWA) from Moscow (N=21) and Gothenburg (N=23) and a corresponding number of age-matched typically developing boys (TDB). EEG spectral power (SP) and SP interhemispheric asymmetry within delta, theta and alpha bands were analyzed. RESULTS: BWA comprised a non-homogeneous group in relation to theta and alpha SP. When four outliers were excluded the only between-group difference in absolute SP was a higher amount of prefrontal delta in BWA. BWA of both samples demonstrated atypical leftward broadband EEG asymmetry with a maximum effect over the mid-temporal regions. Concurrently, the normal leftward asymmetry of mu rhythm was absent in BWA. CONCLUSIONS: The abnormal broadband EEG asymmetry in autism may point to a diminished capacity of right temporal cortex to generate EEG rhythms. The concurrent lack of normal leftward asymmetry of mu rhythm suggests that abnormalities in EEG lateralization in autism may be regionally/functionally specific. SIGNIFICANCE: The data provide evidence for abnormal functional brain lateralization in autism.
Authors: Sara Jane Webb; Emily J H Jones; Kristen Merkle; Kaitlin Venema; Jessica Greenson; Michael Murias; Geraldine Dawson Journal: Child Dev Date: 2011-10-17
Authors: Zening Fu; Yiheng Tu; Xin Di; Yuhui Du; Jing Sui; Bharat B Biswal; Zhiguo Zhang; N de Lacy; V D Calhoun Journal: Neuroimage Date: 2018-06-06 Impact factor: 6.556
Authors: I-Ting Judy Wang; Megan Allen; Darren Goffin; Xinjian Zhu; Andrew H Fairless; Edward S Brodkin; Steve J Siegel; Eric D Marsh; Julie A Blendy; Zhaolan Zhou Journal: Proc Natl Acad Sci U S A Date: 2012-12-10 Impact factor: 11.205
Authors: David M Simon; Cara R Damiano; Tiffany G Woynaroski; Lisa V Ibañez; Michael Murias; Wendy L Stone; Mark T Wallace; Carissa J Cascio Journal: J Autism Dev Disord Date: 2017-09
Authors: T Sigi Hale; Susan L Smalley; Jeff Dang; Grant Hanada; James Macion; James T McCracken; James J McGough; Sandra K Loo Journal: J Psychiatr Res Date: 2009-12-16 Impact factor: 4.791