| Literature DB >> 17581658 |
Stephen G Davies1, A Christopher Garner, Jaqueline V A Ouzman, Paul M Roberts, Andrew D Smith, Emma J Snow, James E Thomson, Juan A Tamayo, Richard J Vickers.
Abstract
Sequential enolate alkylations of (S)-N(1)-methyl-5-methoxy-6-isopropyl-3,6-dihydropyrazin-2-one and (S)-N(1)-p-methoxybenzyl-5-methoxy-6-isopropyl-3,6-dihydropyrazin-2-one proceed with excellent levels of diastereoselectivity (>90% de) affording quaternary alpha-amino acids in high enantiomeric excess (>98% ee) after deprotection and hydrolysis.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17581658 DOI： 10.1039/b704475e
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876