| Literature DB >> 17581237 |
Yuri S Skoblov1, Inna L Karpenko, Maxim V Jasko, Marina K Kukhanova, Valery L Andronova, Georgy A Galegov, Georgy V Sidorov, Nicolai F Myasoedov.
Abstract
The combinational use of acyclovir (ACV) phosphonate esters and alpha(2)-interferon was shown to produce a synergistic effect on inhibition of HSV-1 replication in Vero cell cultures. Unlike other acyclovir phosphonate derivatives studied earlier, ACV H-phosphonate is not an ACV prodrug. On penetrating into the cells, it may be directly converted into ACV monophosphate escaping dephosphonylation-phosphorylation steps.Entities:
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Year: 2007 PMID： 17581237 DOI： 10.1111/j.1747-0285.2007.00517.x
Source DB: PubMed Journal: Chem Biol Drug Des ISSN： 1747-0277 Impact factor: 2.817