STUDY OBJECTIVES: Inflammation is relatively common in individuals with a sleep disorder and is associated with quality of sleep. The purpose of this study was to examine whether inflammation is associated with quality of sleep in healthy individuals. DESIGN & SETTING: Observational study in a General Clinical Research Center. PARTICIPANTS: This study characterized inflammation and polysomno-graphically verified sleep in 124 African American and Caucasian American women and men without a sleep disorder. MEASUREMENTS AND RESULTS: Circulating levels of 3 markers and/or mediators of inflammation known to be elevated in sleep disorders and in cardiovascular disease were determined (interleukin-6 [IL-6] endothelin-1 [ET-1], soluble intercellular adhesion molecule-1 [sICAM-1]). Sleep was characterized by polysomnography. Multiple linear regression analyses showed that increasing age, male sex, and African American ethnicity were independently associated with poorer sleep. After controlling for these variables, higher levels of ET-1 were independently associated with greater sleep latency (P < or = 0.01), greater rapid eye movement (REM) latency (P < or = 0.01), more slow wave sleep (P < or = 0.05), and less stage 1 sleep (P < or = 0.01). Higher IL-6 levels were independently associated with greater REM latency (P < or = 0.05). CONCLUSIONS: The findings suggest that, in individuals without a known sleep disorder, ET-1, a potent vasoconstrictor and mediator of inflammation, is associated with more deep sleep, whereas both ET-1 and IL-6 are associated with increased latency of sleep and of REM. The findings underscore the complex relationships between peripheral markers of inflammation and sleep.
STUDY OBJECTIVES:Inflammation is relatively common in individuals with a sleep disorder and is associated with quality of sleep. The purpose of this study was to examine whether inflammation is associated with quality of sleep in healthy individuals. DESIGN & SETTING: Observational study in a General Clinical Research Center. PARTICIPANTS: This study characterized inflammation and polysomno-graphically verified sleep in 124 African American and Caucasian American women and men without a sleep disorder. MEASUREMENTS AND RESULTS: Circulating levels of 3 markers and/or mediators of inflammation known to be elevated in sleep disorders and in cardiovascular disease were determined (interleukin-6 [IL-6] endothelin-1 [ET-1], soluble intercellular adhesion molecule-1 [sICAM-1]). Sleep was characterized by polysomnography. Multiple linear regression analyses showed that increasing age, male sex, and African American ethnicity were independently associated with poorer sleep. After controlling for these variables, higher levels of ET-1 were independently associated with greater sleep latency (P < or = 0.01), greater rapid eye movement (REM) latency (P < or = 0.01), more slow wave sleep (P < or = 0.05), and less stage 1 sleep (P < or = 0.01). Higher IL-6 levels were independently associated with greater REM latency (P < or = 0.05). CONCLUSIONS: The findings suggest that, in individuals without a known sleep disorder, ET-1, a potent vasoconstrictor and mediator of inflammation, is associated with more deep sleep, whereas both ET-1 and IL-6 are associated with increased latency of sleep and of REM. The findings underscore the complex relationships between peripheral markers of inflammation and sleep.
Authors: Pia Holland Gjørup; Laima Sadauskiene; Jost Wessels; Ole Nyvad; B Strunge; Erling Bjerregaard Pedersen Journal: Am J Hypertens Date: 2007-01 Impact factor: 2.689
Authors: A N Vgontzas; D A Papanicolaou; E O Bixler; A Lotsikas; K Zachman; A Kales; P Prolo; M L Wong; J Licinio; P W Gold; R C Hermida; G Mastorakos; G P Chrousos Journal: J Clin Endocrinol Metab Date: 1999-08 Impact factor: 5.958
Authors: Margo R Genderson; Brinda K Rana; Matthew S Panizzon; Michael D Grant; Rosemary Toomey; Kristen C Jacobson; Hong Xian; Alice Cronin-Golomb; Carol E Franz; William S Kremen; Michael J Lyons Journal: J Sleep Res Date: 2013-03-20 Impact factor: 3.981
Authors: K Løppenthin; B A Esbensen; P Jennum; M Østergaard; A Tolver; T Thomsen; J Midtgaard Journal: Clin Rheumatol Date: 2015-01-27 Impact factor: 2.980
Authors: Bingqian Zhu; Ulf G Bronas; David W Carley; Kathryn Lee; Alana Steffen; Mary C Kapella; Bilgay Izci-Balserak Journal: Ann N Y Acad Sci Date: 2020-05-28 Impact factor: 5.691
Authors: Mary-Frances O'Connor; Julie E Bower; Hyong Jin Cho; J David Creswell; Stoyan Dimitrov; Mary E Hamby; Michael A Hoyt; Jennifer L Martin; Theodore F Robles; Erica K Sloan; Kamala S Thomas; Michael R Irwin Journal: Brain Behav Immun Date: 2009-04-21 Impact factor: 7.217