BACKGROUND: Smoking is a major risk factor for cot death. Many infants smoke passively as a result of parental smoking. This paper reports on infants exposed to a smoking environment and how they accumulate metabolites of cigarette smoke, such as cotinine, which may be physiologically harmful. AIM: To assess cotinine levels in infants of smoking parents. METHOD: Cotinine excretion in urine was assessed in 104 infants, of whom 71 had smoking parents and 33 had non-smoking parents. All cotinine levels were measured at approximately 12 weeks of age. The subjects were selected from a database of infants in developmental physiological studies which assessed the impact of various factors on early postnatal development. RESULTS: On average babies with at least one parent who was a current cigarette smoker excreted 5.58 (95% CI 3.4 to 9.5) times as much cotinine in the urine as did the babies of non-smoking parents. Maternal smoking was the largest contributing factor. Co-sleeping (p = 0.037) and the minimum room temperature (p = 0.028) were significant contributory factors. CONCLUSION: Infants from smoking households accumulate cotinine, a metabolite of nicotine, which may have a detrimental effect on the cardiorespiratory system.
BACKGROUND: Smoking is a major risk factor for cot death. Many infants smoke passively as a result of parental smoking. This paper reports on infants exposed to a smoking environment and how they accumulate metabolites of cigarette smoke, such as cotinine, which may be physiologically harmful. AIM: To assess cotinine levels in infants of smoking parents. METHOD:Cotinine excretion in urine was assessed in 104 infants, of whom 71 had smoking parents and 33 had non-smoking parents. All cotinine levels were measured at approximately 12 weeks of age. The subjects were selected from a database of infants in developmental physiological studies which assessed the impact of various factors on early postnatal development. RESULTS: On average babies with at least one parent who was a current cigarette smoker excreted 5.58 (95% CI 3.4 to 9.5) times as much cotinine in the urine as did the babies of non-smoking parents. Maternal smoking was the largest contributing factor. Co-sleeping (p = 0.037) and the minimum room temperature (p = 0.028) were significant contributory factors. CONCLUSION:Infants from smoking households accumulate cotinine, a metabolite of nicotine, which may have a detrimental effect on the cardiorespiratory system.
Authors: E A Mitchell; P G Tuohy; J M Brunt; J M Thompson; M S Clements; A W Stewart; R P Ford; B J Taylor Journal: Pediatrics Date: 1997-11 Impact factor: 7.124
Authors: Natalie Walker; Vanessa Johnston; Marewa Glover; Christopher Bullen; Adrian Trenholme; Anne Chang; Peter Morris; Catherine Segan; Ngiare Brown; Debra Fenton; Eyvette Hawthorne; Ron Borland; Varsha Parag; Taina Von Blaramberg; Darren Westphal; David Thomas Journal: Nicotine Tob Res Date: 2014-08-25 Impact factor: 4.244