| Literature DB >> 17579456 |
Masayuki Yamashita1, Navnath Dnyanoba Yadav, Takeshi Sawaki, Ikuko Takao, Ikuo Kawasaki, Yasuko Sugimoto, Akemi Miyatake, Kousuke Murai, Ayano Takahara, Ai Kurume, Shunsaku Ohta.
Abstract
The first asymmetric total synthesis of (-)-Linderol A, a potent inhibitor of melanin biosynthesis of cultured B-16 melanoma cells, has been achieved via two key reactions: a diastereoselective [2+2] photocycloaddition of a coumarin-3-carboxylate bearing a chiral auxiliary with 3-methyl-1-butene and a subsequent stereoconvergent transformation of the photoadducts with use of dimethylsulfoxonium methylide to afford a tetrahydrodibenzofuran derivative.Entities:
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Year: 2007 PMID： 17579456 DOI： 10.1021/jo070682+
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354