| Literature DB >> 1757943 |
E H Giannini1, C N Malagon, C Van Kerckhove, J Taylor, D J Lovell, J E Levinson, M H Passo, J Ginsberg, M J Burke, D N Glass.
Abstract
The risk of iridocyclitis in children with early onset pauciarticular juvenile rheumatoid arthritis (EOPA-JRA) has been shown to be associated with certain HLA haplotypes. Our report contains an actuarial analysis, using one-year intervals, of 161 subjects and estimates haplotype specific risks. Individuals who possess the major susceptibility haplotype HLA-DR5 (11) developed eye disease earlier and with a greater frequency than did those with the protective HLA-DR1 haplotype. Highly significant differences were found between the resulting life-table curves for HLA-DR5 and HLA-DR1 positive subjects (p = 0.00003). These time oriented risk estimates may aid clinicians in determining more precisely the probability of iridocyclitis throughout the course of the disease in children with EOPA-JRA.Entities:
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Year: 1991 PMID： 1757943
Source DB: PubMed Journal: J Rheumatol ISSN： 0315-162X Impact factor: 4.666