BACKGROUND:Low anterior resection (LAR) may result in faecal incontinence. This study aimed to identify risk factors for long-term faecal incontinence after total mesorectal excision (TME) with or without preoperative radiotherapy (PRT). METHODS:Between 1996 and 1999, patients with operable rectal cancer were randomized to TME with or without PRT. Eligible patients who underwent LAR were studied retrospectively at 2 years (399 patients) and 5 years (339) after TME. RESULTS: At 5 years after surgery faecal incontinence was reported by 61.5 per cent of patients who had PRT and 38.8 per cent of those who did not (P < 0.001). Excessive blood loss and height of the tumour were associated with long-term faecal incontinence, but only in patients treated with PRT. CONCLUSION:Faecal incontinence is likely to occur after PRT and TME, especially when the perineum is irradiated. Copyright (c) 2007 British Journal of Surgery Society Ltd.
RCT Entities:
BACKGROUND: Low anterior resection (LAR) may result in faecal incontinence. This study aimed to identify risk factors for long-term faecal incontinence after total mesorectal excision (TME) with or without preoperative radiotherapy (PRT). METHODS: Between 1996 and 1999, patients with operable rectal cancer were randomized to TME with or without PRT. Eligible patients who underwent LAR were studied retrospectively at 2 years (399 patients) and 5 years (339) after TME. RESULTS: At 5 years after surgery faecal incontinence was reported by 61.5 per cent of patients who had PRT and 38.8 per cent of those who did not (P < 0.001). Excessive blood loss and height of the tumour were associated with long-term faecal incontinence, but only in patients treated with PRT. CONCLUSION: Faecal incontinence is likely to occur after PRT and TME, especially when the perineum is irradiated. Copyright (c) 2007 British Journal of Surgery Society Ltd.
Authors: Mubarika Alavi; Christopher S Wendel; Robert S Krouse; Larissa Temple; Mark C Hornbrook; Joanna E Bulkley; Carmit K McMullen; Marcia Grant; Lisa J Herrinton Journal: Ann Surg Oncol Date: 2017-08-07 Impact factor: 5.344
Authors: Juliane Kupsch; Thomas Jackisch; Klaus E Matzel; Joerg Zimmer; Andreas Schreiber; Anja Sims; Helmut Witzigmann; Sigmar Stelzner Journal: Int J Colorectal Dis Date: 2018-03-15 Impact factor: 2.571
Authors: Pamela J Atherton; Michele Y Halyard; Jeff A Sloan; Robert C Miller; Richard L Deming; T H Patricia Tai; Kathy J Stien; James A Martenson Journal: Support Care Cancer Date: 2012-11-15 Impact factor: 3.603