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Literature DB >> 17578659

How relevant are GFAP autoantibodies in autism and Tourette Syndrome?

Nikki J Kirkman¹, Jane E Libbey, Thayne L Sweeten, Hilary H Coon, Judith N Miller, Edward K Stevenson, Janet E Lainhart, William M McMahon, Robert S Fujinami.

Abstract

Controversy exists over the role of autoantibodies to central nervous system antigens in autism and Tourette Syndrome. We investigated plasma autoantibody titers to glial fibrillary acidic protein (GFAP) in children with classic onset (33) and regressive onset (26) autism, controls (25, healthy age- and gender-matched) and individuals with Tourette Syndrome (24) by enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to GFAP, not accounted for by age, between the Tourette (significantly lower) and regressive autism groups. However, no differences were found between: classic/regressive; classic/controls; classic/Tourette; regressive/controls; or controls/Tourette. Autoantibody responses against GFAP are unlikely to play a pathogenic role in autism or Tourette Syndrome.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2007 PMID： 17578659 DOI： 10.1007/s10803-007-0398-9

Source DB: PubMed Journal: J Autism Dev Disord ISSN： 0162-3257

45 in total

1. Anti-striatal antibodies in Tourette syndrome cause neuronal dysfunction.

Authors: J J Hallett; C J Harling-Berg; P M Knopf; E G Stopa; L S Kiessling
Journal: J Neuroimmunol Date: 2000-11-01 Impact factor: 3.478

Review 2. B lineage cells in the inflammatory central nervous system environment: migration, maintenance, local antibody production, and therapeutic modulation.

Authors: Edgar Meinl; Markus Krumbholz; Reinhard Hohlfeld
Journal: Ann Neurol Date: 2006-06 Impact factor: 10.422

3. Strong association of the third hypervariable region of HLA-DR beta 1 with autism.

Authors: R P Warren; J D Odell; W L Warren; R A Burger; A Maciulis; W W Daniels; A R Torres
Journal: J Neuroimmunol Date: 1996-07 Impact factor: 3.478

4. The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism.

Authors: C Lord; S Risi; L Lambrecht; E H Cook; B L Leventhal; P C DiLavore; A Pickles; M Rutter
Journal: J Autism Dev Disord Date: 2000-06

Review 5. Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000).

Authors: L F Eng; R S Ghirnikar; Y L Lee
Journal: Neurochem Res Date: 2000-10 Impact factor: 3.996

6. Early regression in social communication in autism spectrum disorders: a CPEA Study.

Authors: Rhiannon Luyster; Jennifer Richler; Susan Risi; Wan-Ling Hsu; Geraldine Dawson; Raphael Bernier; Michelle Dunn; Susan Hepburn; Susan L Hyman; William M McMahon; Julie Goudie-Nice; Nancy Minshew; Sally Rogers; Marian Sigman; M Anne Spence; Wendy A Goldberg; Helen Tager-Flusberg; Fred R Volkmar; Catherine Lord
Journal: Dev Neuropsychol Date: 2005 Impact factor: 2.253

7. Antibodies to neuron-specific antigens in children with autism: possible cross-reaction with encephalitogenic proteins from milk, Chlamydia pneumoniae and Streptococcus group A.

Authors: A Vojdani; A W Campbell; E Anyanwu; A Kashanian; K Bock; E Vojdani
Journal: J Neuroimmunol Date: 2002-08 Impact factor: 3.478

8. HLA-DR4 in families with autism.

Authors: Li-Ching Lee; Andrea A Zachary; Mary S Leffell; Craig J Newschaffer; Karla J Matteson; John D Tyler; Andrew W Zimmerman
Journal: Pediatr Neurol Date: 2006-11 Impact factor: 3.372

9. Antibodies to myelin basic protein in children with autistic behavior.

Authors: V K Singh; R P Warren; J D Odell; W L Warren; P Cole
Journal: Brain Behav Immun Date: 1993-03 Impact factor: 7.217

10. Language and other regression: assessment and timing.

Authors: Wendy A Goldberg; Kathy Osann; Pauline A Filipek; Tracy Laulhere; Kelly Jarvis; Charlotte Modahl; Pamela Flodman; M Anne Spence
Journal: J Autism Dev Disord Date: 2003-12

12 in total

Review 1. Immune dysfunction in autism: a pathway to treatment.

Authors: Milo Careaga; Judy Van de Water; Paul Ashwood
Journal: Neurotherapeutics Date: 2010-07 Impact factor: 7.620

Review 2. Immune-mediated animal models of Tourette syndrome.

Authors: Mady Hornig; W Ian Lipkin
Journal: Neurosci Biobehav Rev Date: 2013-01-10 Impact factor: 8.989

Review 3. Autoimmunity in autism.

Authors: Amanda M Enstrom; Judy A Van de Water; Paul Ashwood
Journal: Curr Opin Investig Drugs Date: 2009-05

4. Are there altered antibody responses to measles, mumps, or rubella viruses in autism?

Authors: Jane E Libbey; Hilary H Coon; Nikki J Kirkman; Thayne L Sweeten; Judith N Miller; Janet E Lainhart; William M McMahon; Robert S Fujinami
Journal: J Neurovirol Date: 2007-06 Impact factor: 2.643

5. Are there enhanced MBP autoantibodies in autism?

Authors: Jane E Libbey; Hilary H Coon; Nikki J Kirkman; Thayne L Sweeten; Judith N Miller; Edward K Stevenson; Janet E Lainhart; William M McMahon; Robert S Fujinami
Journal: J Autism Dev Disord Date: 2007-06-22

6. Aberrant immune responses in a mouse with behavioral disorders.

Authors: Yong Heo; Yubin Zhang; Donghong Gao; Veronica M Miller; David A Lawrence
Journal: PLoS One Date: 2011-07-20 Impact factor: 3.240

7. Further characterization of autoantibodies to GABAergic neurons in the central nervous system produced by a subset of children with autism.

Authors: Sharifia Wills; Christy C Rossi; Jeffrey Bennett; Veronica Martinez-Cerdeño; Paul Ashwood; David G Amaral; Judy Van de Water
Journal: Mol Autism Date: 2011-04-26 Impact factor: 7.509