Bilateral Brown syndrome in three siblings.

The vast majority of cases of Brown syndrome are considered to be of a nonfamilial, sporadic nature. Documented instances of familial transmission are rare. All three siblings in one family pedigree showed bilateral Brown syndrome. Other family members were reportedly unaffected. The current cases, along with previous reports, support the concept that a subset of congenital Brown syndrome may have a strong hereditary basis, being transmitted either as an autosomal recessive genetic trait or an autosomal dominant disorder with decreased penetrance.