Literature DB >> 175780

Dogfish M4 lactate dehydrogenase: reversible inactivation by pyridoxal 5'-phosphate and complete protection in complexes that mimic the active ternary complex.

S S Chen, P C Engel.   

Abstract

Dogfish M4 lactate dehydrogenase, like the corresponding pig enzyme, is inactivated by pyridoxal 5'-phosphate through modification of a single essential lysine residue. The activity is completely protected in the complexes E-NAD+-oxalate, E-NADH-oxamate and E-(NAD+-pyruvate adduct), but only partially protected in E-NAD+, E-NADH, E-NAD+-oxamate and E-NADH-oxalate.

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Year:  1975        PMID： 175780      PMCID： PMC1172378          DOI： 10.1042/bj1510447

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  9 in total

1.  Lactic dehydrogenase. VIII. Binding of oxamate and of oxalate by enzyme-coenzyme complexes.

Authors:  W B NOVOA; G W SCHWERT
Journal:  J Biol Chem       Date:  1961-07       Impact factor: 5.157

2.  Lactic dehydrogenase. V. Inhibition by oxamate and by oxalate.

Authors:  W B NOVOA; A D WINER; A J GLAID; G W SCHWERT
Journal:  J Biol Chem       Date:  1959-05       Impact factor: 5.157

3.  Lactic dehydrogenase. VII. Fluorescence spectra of ternary complexes of lactic dehydrogenase, reduced diphosphopyridine nucleotide, and carboxylic acids.

Authors:  A D WINER; G W SCHWERT
Journal:  J Biol Chem       Date:  1959-05       Impact factor: 5.157

4.  Horse liver alcohol dehydrogenase. A study of the essential lysine residue.

Authors:  S S Chen; P C Engel
Journal:  Biochem J       Date:  1975-09       Impact factor: 3.857

5.  Modification of pig M4 lactate dehydrogenase by pyridoxal 5'-phosphate. Demonstration of an essential lysine residue.

Authors:  S S Chen; P C Engel
Journal:  Biochem J       Date:  1975-07       Impact factor: 3.857

6.  The equilibrium position of the reaction of bovine liver glutamate dehydrogenase with pyridoxal5'-phosphate. A demonstration that covalent modification with this reagent completely abolishes catalytic activity.

Authors:  S S Chen; P C Engel
Journal:  Biochem J       Date:  1975-05       Impact factor: 3.857

7.  The structure of the abortive diphosphopyridine nucleotide-pyruvate-lactate dehydrogenase ternary complex as determined by proton magnetic resonance analysis.

Authors:  L J Arnold; N O Kaplan
Journal:  J Biol Chem       Date:  1974-01-25       Impact factor: 5.157

8.  Structural constraints of possible mechanisms of lactate dehydrogenase as shown by high resolution studies of the apoenzyme and a variety of enzyme complexes.

Authors:  M G Rossmann; M J Adams; M Buehner; G C Ford; M L Hackert; P J Lentz; A McPherson; R W Schevitz; I E Smiley
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1972

9.  Structure-function relationships in lactate dehydrogenase.

Authors:  M J Adams; M Buehner; K Chandrasekhar; G C Ford; M L Hackert; A Liljas; M G Rossmann; I E Smiley; W S Allison; J Everse; N O Kaplan; S S Taylor
Journal:  Proc Natl Acad Sci U S A       Date:  1973-07       Impact factor: 11.205
  9 in total

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