Richard Deulofeut1, Golde Dudell, Augusto Sola. 1. Emory University School of Medicine, Division of Neonatal-Perinatal Medicine, Atlanta, Georgia, USA. deulofeut@post.harvard.edu
Abstract
OBJECTIVE: To examine gender-specific differences in response to the O(2) saturation (SpO(2)) targets aimed at avoiding hyperoxia in very low birth weight infants (VLBW). METHODS: Analysis of a prospectively collected database of all infants </=1250 g in two perinatal centres. A change was instituted in January 2003 with the objective of avoiding hyperoxia with target SpO(2) at 85-93% (period II). Prior to this, SpO(2) high alarms were set at 100% and low alarms at 92% (period I; from January 2000 to December 2002). RESULTS: Of the 497 infants that met enrolment criteria, 297 (60%) were born during period I and 140 (47%) of them were male. During period II, 200 infants were born and 101 (50%) were male. Analysis by gender showed that the rate of retinopathy of prematurity, bronchopulmonary dysplasia and length of stay is significantly better for female infants than males on period II compared to period I. Neither gender experienced increased short-term neurological morbidity in response to lower SpO(2) targets. CONCLUSIONS: There is a significant gender-specific difference favouring females in the beneficial effects produced by avoiding high SpO(2) and hyperoxia, with no difference in the distribution of any potential short-term detrimental effects.
OBJECTIVE: To examine gender-specific differences in response to the O(2) saturation (SpO(2)) targets aimed at avoiding hyperoxia in very low birth weight infants (VLBW). METHODS: Analysis of a prospectively collected database of all infants </=1250 g in two perinatal centres. A change was instituted in January 2003 with the objective of avoiding hyperoxia with target SpO(2) at 85-93% (period II). Prior to this, SpO(2) high alarms were set at 100% and low alarms at 92% (period I; from January 2000 to December 2002). RESULTS: Of the 497 infants that met enrolment criteria, 297 (60%) were born during period I and 140 (47%) of them were male. During period II, 200 infants were born and 101 (50%) were male. Analysis by gender showed that the rate of retinopathy of prematurity, bronchopulmonary dysplasia and length of stay is significantly better for female infants than males on period II compared to period I. Neither gender experienced increased short-term neurological morbidity in response to lower SpO(2) targets. CONCLUSIONS: There is a significant gender-specific difference favouring females in the beneficial effects produced by avoiding high SpO(2) and hyperoxia, with no difference in the distribution of any potential short-term detrimental effects.
Authors: Min Yee; R James White; Hani A Awad; Wendy A Bates; Sharon A McGrath-Morrow; Michael A O'Reilly Journal: Am J Pathol Date: 2011-05-06 Impact factor: 4.307
Authors: Till Scheuer; Yuliya Sharkovska; Victor Tarabykin; Katharina Marggraf; Vivien Brockmöller; Christoph Bührer; Stefanie Endesfelder; Thomas Schmitz Journal: Mol Neurobiol Date: 2017-05-25 Impact factor: 5.590
Authors: Juliann M Di Fiore; Jeffrey N Bloom; Faruk Orge; Alison Schutt; Mark Schluchter; Vinay K Cheruvu; Michele Walsh; Neil Finer; Richard J Martin Journal: J Pediatr Date: 2010-03-20 Impact factor: 4.406
Authors: Min Yee; Patricia R Chess; Sharon A McGrath-Morrow; Zhengdong Wang; Robert Gelein; Rui Zhou; David A Dean; Robert H Notter; Michael A O'Reilly Journal: Am J Physiol Lung Cell Mol Physiol Date: 2009-07-17 Impact factor: 5.464
Authors: Anantha Harijith; Srikanth Pendyala; Narsa M Reddy; Tao Bai; Peter V Usatyuk; Evgeny Berdyshev; Irina Gorshkova; Long Shuang Huang; Vijay Mohan; Steve Garzon; Prasad Kanteti; Sekhar P Reddy; J Usha Raj; Viswanathan Natarajan Journal: Am J Pathol Date: 2013-08-08 Impact factor: 4.307
Authors: Waldemar A Carlo; Neil N Finer; Michele C Walsh; Wade Rich; Marie G Gantz; Abbot R Laptook; Bradley A Yoder; Roger G Faix; Abhik Das; W Kenneth Poole; Kurt Schibler; Nancy S Newman; Namasivayam Ambalavanan; Ivan D Frantz; Anthony J Piazza; Pablo J Sánchez; Brenda H Morris; Nirupama Laroia; Dale L Phelps; Brenda B Poindexter; C Michael Cotten; Krisa P Van Meurs; Shahnaz Duara; Vivek Narendran; Beena G Sood; T Michael O'Shea; Edward F Bell; Richard A Ehrenkranz; Kristi L Watterberg; Rosemary D Higgins Journal: N Engl J Med Date: 2010-05-16 Impact factor: 91.245