BACKGROUND: There is an increasing evidence to indicate that stress can influence skin disease and cutaneous functions. Previous studies have shown that stress alters the murine hair cycle; however, these studies have been carried out by using mouse models in which the hair cycle is forcibly synchronized after depilation. OBJECTIVE: To examine whether foot shock stress (FS) changes the spontaneous hair cycle in a non-depilated animal model, and to evaluate the role of mast cells and substance P (SP) in the influence of stress on the hair cycle. METHODS: Changes in the spontaneous hair cycle and the inhibitory effects of a specific SP NK1 receptor antagonist were examined in non-depilated mice during 3-4 weeks of FS. RESULTS: Foot shock stress prolonged the telogen stage of the hair cycle and delayed the induction of the subsequent anagen stage in the animal model. FS caused an increase in the ratio of de-granulated mast cells in the skin, an increase in the number of TUNEL-positive cells, and a decrease in the number of Ki67-positive cells. The NK1 receptor antagonist, WIN 62577, inhibited these stress responses. CONCLUSION: Our results strongly support previous work, demonstrating that stress alters active hair-cycling in vivo through the action of SP.
BACKGROUND: There is an increasing evidence to indicate that stress can influence skin disease and cutaneous functions. Previous studies have shown that stress alters the murine hair cycle; however, these studies have been carried out by using mouse models in which the hair cycle is forcibly synchronized after depilation. OBJECTIVE: To examine whether foot shock stress (FS) changes the spontaneous hair cycle in a non-depilated animal model, and to evaluate the role of mast cells and substance P (SP) in the influence of stress on the hair cycle. METHODS: Changes in the spontaneous hair cycle and the inhibitory effects of a specific SPNK1 receptor antagonist were examined in non-depilated mice during 3-4 weeks of FS. RESULTS:Foot shock stress prolonged the telogen stage of the hair cycle and delayed the induction of the subsequent anagen stage in the animal model. FS caused an increase in the ratio of de-granulated mast cells in the skin, an increase in the number of TUNEL-positive cells, and a decrease in the number of Ki67-positive cells. The NK1 receptor antagonist, WIN 62577, inhibited these stress responses. CONCLUSION: Our results strongly support previous work, demonstrating that stress alters active hair-cycling in vivo through the action of SP.
Authors: Andrzej T Slominski; Michal A Zmijewski; Blazej Zbytek; Desmond J Tobin; Theoharis C Theoharides; Jean Rivier Journal: Endocr Rev Date: 2013-08-12 Impact factor: 19.871
Authors: Melinda A Novak; Mark T Menard; Saif N El-Mallah; Kendra Rosenberg; Corrine K Lutz; Julie Worlein; Kris Coleman; Jerrold S Meyer Journal: Am J Primatol Date: 2016-03-23 Impact factor: 2.371
Authors: Deborah A Vanderford; Paula K Greer; Julie M Sharp; Maciej Chichlowski; D Clayburn Rouse; M Angelica Selim; Laura P Hale Journal: Exp Dermatol Date: 2010-01-22 Impact factor: 3.960