Literature DB >> 17576025

Gantrez AN nanoparticles as an adjuvant for oral immunotherapy with allergens.

Sara Gómez1, Carlos Gamazo, Beatriz San Roman, Marta Ferrer, Maria Luisa Sanz, Juan M Irache.   

Abstract

The aim of this study was to investigate the adjuvant properties of oral-administered Gantrez AN nanoparticles with ovalbumin (as allergen model) and, in some cases, lipopolysaccharide of Brucella ovis as immunomodulator. For this purpose, BALB/c mice were administered by oral gavage with OVA nanoparticles and both Th1 and Th2 markers (IgG2a and IgG1, respectively) were enhanced. On the other hand, these carriers administered by oral route were able to protect a model of sensitized mice to ovalbumin from anaphylactic shock. These results are highly suggestive for the valuable use of Gantrez nanoparticles in oral immunotherapy with allergens.

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Year:  2007        PMID： 17576025     DOI： 10.1016/j.vaccine.2007.05.020

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  12 in total

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Review 2.  Nanoparticles and the immune system.

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Authors:  Carlos Gamazo; Carmen D'Amelio; Gabriel Gastaminza; Marta Ferrer; Juan M Irache
Journal:  Hum Vaccin Immunother       Date:  2017-10-03       Impact factor: 3.452

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Review 5.  Current understanding of interactions between nanoparticles and the immune system.

Authors:  Marina A Dobrovolskaia; Michael Shurin; Anna A Shvedova
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6.  Immunogenicity of peanut proteins containing poly(anhydride) nanoparticles.

Authors:  Juliana De S Rebouças; Juan M Irache; Ana I Camacho; Gabriel Gastaminza; María L Sanz; Marta Ferrer; Carlos Gamazo
Journal:  Clin Vaccine Immunol       Date:  2014-06-04

Review 7.  Enhancing the Safety and Efficacy of Food Allergy Immunotherapy: a Review of Adjunctive Therapies.

Authors:  Yamini V Virkud; Julie Wang; Wayne G Shreffler
Journal:  Clin Rev Allergy Immunol       Date:  2018-10       Impact factor: 8.667

8.  Lipid nanoparticles as delivery vehicles for the Parietaria judaica major allergen Par j 2.

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Review 9.  Nanoparticulate adjuvants and delivery systems for allergen immunotherapy.

Authors:  Juliana De Souza Rebouças; Irene Esparza; Marta Ferrer; María Luisa Sanz; Juan Manuel Irache; Carlos Gamazo
Journal:  J Biomed Biotechnol       Date:  2012-02-26

Review 10.  Demystifying particle-based oral vaccines.

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Journal:  Expert Opin Drug Deliv       Date:  2021-07-06       Impact factor: 8.129
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