| Literature DB >> 17576019 |
Lili Li1, Zijian Li, Shanghui Zhou, Lanbo Xiao, Lili Guo, Yongguang Tao, Min Tang, Ying Shi, Wei Li, Wei Yi, Ya Cao.
Abstract
Epstein-Barr virus encoded latent membrane protein 1 (LMP1), an oncogenic protein, plays an important role in the carcinogenesis of nasopharyngeal carcinoma. The MDM2 gene is a cellular pro-oncogene that is abnormally up-regulated in human tumors. MDM2 is overexpressed in nasopharyngeal carcinoma, which is associated with the presence of EBV and cervical lymph node metastasis. Because MDM2 is capable of self-ubiquitination, and the ubiquitin proteasome pathway-dependent degradation is an important mechanism for regulating MDM2 levels in cells. Here we show that LMP1 augment MDM2 protein expression in dose-dependent level, and also lead to a drastic accumulation of ubiquitinated MDM2 species, this effect is associated with the stability of MDM2 modulated by LMP1. This is the first time to explain LMP1-regulated MDM2 through a post-ubiquitination mechanism.Entities:
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Year: 2007 PMID： 17576019 DOI： 10.1016/j.virusres.2007.05.013
Source DB: PubMed Journal: Virus Res ISSN： 0168-1702 Impact factor: 3.303