Literature DB >> 17574524

Is there a recommended maximum starting dose of FSH in IVF?

Luk Rombauts1.   

Abstract

This report reviews and discusses the existing evidence on recommended FSH doses in IVF cycles. A comprehensive search for relevant data was performed in the Cochrane Library, MEDLINE, EMBASE and NICE clinical guidelines database, and the reference lists of manuscripts. A good body of evidence exists looking at starting doses of FSH for first IVF attempts. Only one randomised controlled trial was identified looking at the efficacy of increasing doses during an IVF cycle. Some observational studies dealt with the question whether a suboptimal ovarian response should be managed by an increased FSH dose in a subsequent cycle, but no randomised trials addressed this issue.

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Year:  2007        PMID： 17574524      PMCID： PMC3454944          DOI： 10.1007/s10815-007-9134-9

Source DB:  PubMed          Journal:  J Assist Reprod Genet        ISSN： 1058-0468            Impact factor:   3.412


  28 in total

1.  A randomized, double-blind clinical trial using fixed daily doses of 100 or 200 IU of recombinant FSH in ICSI cycles.

Authors:  H J Out; I David; R Ron-El; S Friedler; E Shalev; J Geslevich; J Dor; A Shulman; Z Ben-Rafael; B Fisch; M Dirnfeld
Journal:  Hum Reprod       Date:  2001-06       Impact factor: 6.918

2.  A group-comparative, randomized, double-blind comparison of the efficacy and efficiency of two fixed daily dose regimens (100- and 200-IU) of recombinant follicle stimulating hormone (rFSH, Puregon) in Asian women undergoing ovarian stimulation for IVF/ICSI.

Authors:  Eric H M Hoomans; Bernard B Mulder
Journal:  J Assist Reprod Genet       Date:  2002-10       Impact factor: 3.412

3.  A randomized, double-blind, multicentre clinical trial comparing starting doses of 150 and 200 IU of recombinant FSH in women treated with the GnRH antagonist ganirelix for assisted reproduction.

Authors:  Henk J Out; Anthony Rutherford; Richard Fleming; Clement C K Tay; Geoffrey Trew; William Ledger; David Cahill
Journal:  Hum Reprod       Date:  2004-01       Impact factor: 6.918

4.  Increasing the daily dose of recombinant follicle stimulating hormone (Puregon) does not compensate for the age-related decline in retrievable oocytes after ovarian stimulation.

Authors:  H J Out; D D Braat; B M Lintsen; T Gurgan; O Bukulmez; O Gökmen; G Keles; P Caballero; J M González; F Fábregues; J Balasch; R Roulier
Journal:  Hum Reprod       Date:  2000-01       Impact factor: 6.918

5.  A prospective, randomized comparison of two starting doses of recombinant FSH in combination with cetrorelix in women undergoing ovarian stimulation for IVF/ICSI.

Authors:  M Wikland; C Bergh; K Borg; T Hillensjö; C M Howles; A Knutsson; L Nilsson; M Wood
Journal:  Hum Reprod       Date:  2001-08       Impact factor: 6.918

6.  A double-blind clinical trial comparing a fixed daily dose of 150 and 250 IU of recombinant follicle-stimulating hormone in women undergoing in vitro fertilization.

Authors: 
Journal:  Fertil Steril       Date:  2001-11       Impact factor: 7.329

Review 7.  Efficacy of natural cycle IVF: a review of the literature.

Authors:  M J Pelinck; A Hoek; A H M Simons; M J Heineman
Journal:  Hum Reprod Update       Date:  2002 Mar-Apr       Impact factor: 15.610

8.  A prospective randomized clinical trial comparing 150 IU and 225 IU of recombinant follicle-stimulating hormone (Gonal-F*) in a fixed-dose regimen for controlled ovarian stimulation in in vitro fertilization treatment.

Authors:  Peter Y K Yong; Sandra Brett; David T Baird; K J Thong
Journal:  Fertil Steril       Date:  2003-02       Impact factor: 7.329

Review 9.  Clinical management of low ovarian response to stimulation for IVF: a systematic review.

Authors:  B C Tarlatzis; L Zepiridis; G Grimbizis; J Bontis
Journal:  Hum Reprod Update       Date:  2003 Jan-Feb       Impact factor: 15.610

10.  Increasing the gonadotrophin dose in the course of an in vitro fertilization cycle does not rectify an initial poor response.

Authors:  Y Khalaf; Tarek El-Toukhy; A Taylor; P Braude
Journal:  Eur J Obstet Gynecol Reprod Biol       Date:  2002-07-10       Impact factor: 2.435
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  3 in total

Review 1.  Melatonin: shedding light on infertility?--A review of the recent literature.

Authors:  Shavi Fernando; Luk Rombauts
Journal:  J Ovarian Res       Date:  2014-10-21       Impact factor: 4.234

2.  The Essential Role of Body Weight in Adjusting Gn Dosage to Prevent High Ovarian Response for Women With PCOS During IVF: A Retrospective Study.

Authors:  Rujun Zeng; Hanxiao Chen; Xun Zeng; Lang Qin
Journal:  Front Endocrinol (Lausanne)       Date:  2022-07-01       Impact factor: 6.055

3.  The Effect of Dose Adjustments in a Subsequent Cycle of Women With Suboptimal Response Following Conventional Ovarian Stimulation.

Authors:  Panagiotis Drakopoulos; Samuel Santos-Ribeiro; Ernesto Bosch; Juan Garcia-Velasco; Christophe Blockeel; Alessia Romito; Herman Tournaye; Nikolaos P Polyzos
Journal:  Front Endocrinol (Lausanne)       Date:  2018-07-23       Impact factor: 5.555
  3 in total

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