Literature DB >> 17574488

Effects of in ovo administration of DHEA on lipid metabolism and hepatic lipogenetic genes expression in broiler chickens during embryonic development.

Sumei Zhao1, Haitian Ma, Sixiang Zou, Weihua Chen.   

Abstract

In order to study the mechanism of DHEA (Dehydroepiandrosterone) in reducing fat in broiler chickens during embryonic development, fertilized eggs were administrated with DHEA before incubation and its effect on lipid metabolism and expression of hepatic lipogenetic genes was investigated. The mRNA levels of acetyl CoA carboxylase (ACC), fatty acid synthase (FAS), malic enzyme (ME), apolipoprotein B100 (apoB100) and sterol regulator element binding protein-1c (SREBP-1c) were determined using real time quantitative PCR. Samples of livers were collected from the chickens on days 9, 14, and 19 of embryonic development as well as at hatching. Blood samples were extracted on days 14, 19 of incubation and at hatching. The results showed that DHEA decreased the concentration of triacyglycerol in the blood and the content in liver, and the mRNA levels of ACC, FAS, ME, SREBP-1c and apoB. This suggested that DHEA decreased the expression of hepatic lipogenetic genes and suppressed triglycerols transport, by which it reduced the deposition of fat in adipose tissue in broiler chickens during embryonic development and hatching.

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Year:  2007        PMID： 17574488     DOI： 10.1007/s11745-007-3068-y

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.646


  44 in total

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4.  Use of comparative proteomics to identify key proteins related to hepatic lipid metabolism in broiler chickens: evidence accounting for differential fat deposition between strains.

Authors:  Jianzhen Huang; Xue Tang; Jiming Ruan; Haitian Ma; Sixiang Zou
Journal:  Lipids       Date:  2009-11-29       Impact factor: 1.880

5.  The effects of H3N2 swine influenza virus infection on TLRs and RLRs signaling pathways in porcine alveolar macrophages.

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Journal:  Virol J       Date:  2015-04-14       Impact factor: 4.099

6.  Identification and characterization of genes that control fat deposition in chickens.

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7.  (-)-Hydroxycitric acid reduced fat deposition via regulating lipid metabolism-related gene expression in broiler chickens.

Authors:  Jing Han; Longlong Li; Dian Wang; Haitian Ma
Journal:  Lipids Health Dis       Date:  2016-02-24       Impact factor: 3.876
  7 in total

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