| Literature DB >> 17574424 |
Wuhong Chen1, Zhaohu Lin, Mengmeng Ning, Chunhao Yang, Xueming Yan, Yuyuan Xie, Xu Shen, Ming-Wei Wang.
Abstract
3-Aryl-tetrahydroquinolines, aza analogues of equol, are synthesized and evaluated for their binding properties to the estrogen receptors ERalpha and ERbeta. Several of these compounds exhibited binding selectivity for ER similar to that of genistein. Compounds 8c and 8d were found to have dual actions: antagonists for ERalpha and agonists for ERbeta in a yeast two-hybrid assay. These compounds have no estrogenic effects on the uterus and bone in vivo.Entities:
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Year: 2007 PMID： 17574424 DOI： 10.1016/j.bmc.2007.05.071
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641