| Literature DB >> 17574417 |
Philip Wickens1, Harold Kluender, Julie Dixon, Catherine Brennan, Furahi Achebe, Antonella Bacchiocchi, Don Bankston, Donald Bierer, Michael Brands, Debbie Braun, Melissa S Brown, Chih-Yuan Chuang, Jacques Dumas, Istvan Enyedy, Gloria Hofilena, Zhenqiu Hong, Tim Housley, Benjamin Jones, Uday Khire, Charles Kreiman, Ellalahewage Kumarasinghe, Timothy Lowinger, Ronda Ott-Morgan, Louise Perkins, Barton Phillips, Robert Schoenleber, William J Scott, Ryan Sheeler, Anikó Redman, Xiuying Sun, Ian Taylor, Lei Wang, Scott Wilhelm, Xiaomei Zhang, Mingbao Zhang, Elizabeth Sullivan, Christopher Carter, Mark Miglarese, Joan Levy.
Abstract
Novel anthranilamides were surprisingly found to exert additional activity on B-RAF. Corresponding thiophene, pyrazole, and thiazole core analogs were prepared as VEGFR-2 inhibitors with c-KIT, and B-RAF activity. Compounds in the phenyl, thiophene, and thiazole series are in vivo active.Entities:
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Year: 2007 PMID： 17574417 DOI： 10.1016/j.bmcl.2007.02.075
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823