| Literature DB >> 17574412 |
Jeffrey A Pfefferkorn1, Yuntao Song, Kuai-Lin Sun, Steven R Miller, Bharat K Trivedi, Chulho Choi, Roderick J Sorenson, Larry D Bratton, Paul C Unangst, Scott D Larsen, Toni-Jo Poel, Xue-Min Cheng, Chitase Lee, Noe Erasga, Bruce Auerbach, Valerie Askew, Lisa Dillon, Jeffrey C Hanselman, Zhiwu Lin, Gina Lu, Andrew Robertson, Karl Olsen, Thomas Mertz, Catherine Sekerke, Alexander Pavlovsky, Melissa S Harris, Graeme Bainbridge, Nicole Caspers, Huifen Chen, Matthias Eberstadt.
Abstract
This manuscript describes the design and synthesis of a series of pyrrole-based inhibitors of HMG-CoA reductase for the treatment of hypercholesterolemia. Analogs were optimized using structure-based design and physical property considerations resulting in the identification of 44, a hepatoselective HMG-CoA reductase inhibitor with excellent acute and chronic efficacy in a pre-clinical animal models.Entities:
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Year: 2007 PMID： 17574412 DOI： 10.1016/j.bmcl.2007.05.096
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823