| Literature DB >> 17574411 |
Jeffrey A Pfefferkorn1, Chulho Choi, Yuntao Song, Bharat K Trivedi, Scott D Larsen, Valerie Askew, Lisa Dillon, Jeffrey C Hanselman, Zhiwu Lin, Gina Lu, Andrew Robertson, Catherine Sekerke, Bruce Auerbach, Alexander Pavlovsky, Melissa S Harris, Graeme Bainbridge, Nicole Caspers.
Abstract
Using structure-based design, a novel series of conformationally restricted, pyrrole-based inhibitors of HMG-CoA reductase were discovered. Leading analogs demonstrated potent inhibition of cholesterol synthesis in both in vitro and in vivo models and may be useful for the treatment of hypercholesterolemia and related lipid disorders.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17574411 DOI： 10.1016/j.bmcl.2007.05.097
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823