| Literature DB >> 17574410 |
Adrian Hall1, Susan H Brown, Anita Chowdhury, Gerard M P Giblin, Mairi Gibson, Mark P Healy, David G Livermore, Richard J McArthur Wilson, Alan Naylor, D Anthony Rawlings, Shilina Roman, Emma Ward, Caroline Willay.
Abstract
A novel series of oxadiazole EP1 receptor antagonists was identified by replacing the amide of a known glycine sulfonamide derivative with a 1,3,4-oxadiazole. Optimization of the substitution patterns on the three aromatic rings led to the identification of high affinity EP1 receptor antagonists. The derivative with highest affinity displayed a binding IC50 of 2.5 nM (pIC50 8.6).Entities:
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Year: 2007 PMID： 17574410 DOI： 10.1016/j.bmcl.2007.06.014
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823