| Literature DB >> 17574016 |
Abstract
Defects in protein trafficking within the cell body and cilia are thought to underlie the human disease Bardet-Biedl syndrome (BBS). In this issue, Nachury et al. (2007) reveal that a large complex of proteins implicated in BBS cooperates with Rabin8-the GTP exchange factor for the small GTPase Rab8-to promote cilia formation and presumably movement of membrane proteins from the cell into the cilium.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17574016 DOI： 10.1016/j.cell.2007.05.049
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582