Literature DB >> 17573892

Thrombin generation: the functional role of alpha-2-macroglobulin and influence of developmental haemostasis.

V Ignjatovic1, A Greenway, R Summerhayes, P Monagle.   

Abstract

Currently available chromogenic and fluorogenic substrates for endogenous thrombin potential (ETP) measurement are cleaved by both free (active) and alpha-2-macroglobulin-bound (inactive) thrombin, leading to an overestimation of ETP. Commercial methods for ETP measurement determine this using a mathematical algorithm, which assumes the contribution of alpha-2-macroglobulin to the ETP. This limits application of such methods to populations where variation in alpha-2-macroglobulin concentrations is observed, primarily children. This study examined the contribution of alpha-2-macroglobulin-bound thrombin to the ETP measurement in neonates, children and adults, to determine whether automated methods are appropriate for use in neonates and children.

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Year:  2007        PMID： 17573892     DOI： 10.1111/j.1365-2141.2007.06663.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  7 in total

1.  Alpha-2-Macroglobulin Is Acutely Sensitive to Freezing and Lyophilization: Implications for Structural and Functional Studies.

Authors:  Amy R Wyatt; Janet R Kumita; Natalie E Farrawell; Christopher M Dobson; Mark R Wilson
Journal:  PLoS One       Date:  2015-06-23       Impact factor: 3.240

2.  Thrombin generation assays for global evaluation of the hemostatic system: perspectives and limitations.

Authors:  Rita Carolina Figueiredo Duarte; Cláudia Natália Ferreira; Danyelle Romana Alves Rios; Helton José Dos Reis; Maria das Graças Carvalho
Journal:  Rev Bras Hematol Hemoter       Date:  2017-05-09

3.  Global assays and the management of oral anticoagulation.

Authors:  Herm Jan M Brinkman
Journal:  Thromb J       Date:  2015-02-10

4.  Impaired fibrinolysis and lower levels of plasma α2-macroglobulin are associated with an increased risk of severe asthma exacerbations.

Authors:  Stanislawa Bazan-Socha; Lucyna Mastalerz; Agnieszka Cybulska; Lech Zareba; Romy Kremers; Michal Zabczyk; Grazyna Pulka; Teresa Iwaniec; Jan G Bazan; Coenraad Hemker; Anetta Undas
Journal:  Sci Rep       Date:  2017-09-08       Impact factor: 4.379

Review 5.  A review of commercially available thrombin generation assays.

Authors:  Jeremy Kintigh; Paul Monagle; Vera Ignjatovic
Journal:  Res Pract Thromb Haemost       Date:  2017-10-16

6.  Thromboinflammation in COVID-19: Can α2 -macroglobulin help to control the fire?

Authors:  Rainer Seitz; Lutz Gürtler; Wolfgang Schramm
Journal:  J Thromb Haemost       Date:  2020-12-19       Impact factor: 16.036

Review 7.  Thrombin generation assays are versatile tools in blood coagulation analysis: A review of technical features, and applications from research to laboratory routine.

Authors:  François Depasse; Nikolaus B Binder; Julia Mueller; Thomas Wissel; Stephan Schwers; Matthias Germer; Björn Hermes; Peter L Turecek
Journal:  J Thromb Haemost       Date:  2021-09-26       Impact factor: 16.036
  7 in total

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