| Literature DB >> 17572681 |
Wolfram Goessling1, Trista E North, Leonard I Zon.
Abstract
Zebrafish are a valuable vertebrate model to study carcinogenesis, but noninvasive imaging is challenging because adult fish are not transparent. Here we show that tumors could be readily detected in vivo using high-resolution microscopic ultrasound in zebrafish. We successfully obtained tissue perfusion calculations and cellular aspirates, and analyzed tumor progression and response to treatment. Ultrasound biomicroscopy allows longitudinal studies of tumor development and real-time assessment of therapeutic effects in zebrafish.Entities:
Mesh：
Year: 2007 PMID： 17572681 DOI： 10.1038/nmeth1059
Source DB: PubMed Journal: Nat Methods ISSN： 1548-7091 Impact factor: 28.547