Literature DB >> 17572512

Upregulation of thrombospondin-1(TSP-1) and its binding partners, CD36 and CD47, in sporadic inclusion body myositis.

Mohammad Salajegheh1, Raghavan Raju, Jens Schmidt, Marinos C Dalakas.   

Abstract

The TSP1/CD36/CD47-complex is involved in T cell expansion and inflammatory responses to beta-amyloid, both relevant to IBM. We report on the mRNA and protein expression of TSP1/ CD36 /CD47-complex in IBM muscles and in human myoblasts after cytokine stimulation. The TSP1/CD36 /CD47 was upregulated in IBM. TSP1 immunolocalized to the connective tissue contiguous to inflammation and CD36/CD47 on the myofibers and CD8+ cells. Further, TNF-alpha upregulated the production of TSP1 and CD47 by myoblasts. The TSP-complex is another inflammatory mediator associated with chronic inflammation in IBM that may perpetuate the immune responses to local antigens in response to TNF-alpha.

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Year:  2007        PMID： 17572512     DOI： 10.1016/j.jneuroim.2007.04.022

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  14 in total

1.  Thrombospondin-1 Production Regulates the Inflammatory Cytokine Secretion in THP-1 Cells Through NF-κB Signaling Pathway.

Authors:  Tian Xing; Yao Wang; Wen-Jie Ding; Yuan-Ling Li; Xiao-Dong Hu; Cong Wang; Ao Ding; Ji-Long Shen
Journal:  Inflammation       Date:  2017-10       Impact factor: 4.092

2.  Thrombospondin 1 activates the macrophage Toll-like receptor 4 pathway.

Authors:  Yanzhang Li; Xinyu Qi; Xiaopeng Tong; Shuxia Wang
Journal:  Cell Mol Immunol       Date:  2013-08-19       Impact factor: 11.530

3.  Microvascular Dysfunction Following Multiwalled Carbon Nanotube Exposure Is Mediated by Thrombospondin-1 Receptor CD47.

Authors:  William Kyle Mandler; Timothy R Nurkiewicz; Dale W Porter; Eric E Kelley; Ivan Mark Olfert
Journal:  Toxicol Sci       Date:  2018-09-01       Impact factor: 4.849

Review 4.  Inclusion body myositis: review of recent literature.

Authors:  Steven A Greenberg
Journal:  Curr Neurol Neurosci Rep       Date:  2009-01       Impact factor: 5.081

Review 5.  Thrombospondin-1: multiple paths to inflammation.

Authors:  Zenaida Lopez-Dee; Kenneth Pidcock; Linda S Gutierrez
Journal:  Mediators Inflamm       Date:  2011-07-03       Impact factor: 4.711

6.  Inclusion body myositis: laser microdissection reveals differential up-regulation of IFN-γ signaling cascade in attacked versus nonattacked myofibers.

Authors:  Jana Ivanidze; Reinhard Hoffmann; Hanns Lochmüller; Andrew G Engel; Reinhard Hohlfeld; Klaus Dornmair
Journal:  Am J Pathol       Date:  2011-09       Impact factor: 4.307

7.  Thrombospondin-1 production is enhanced by Porphyromonas gingivalis lipopolysaccharide in THP-1 cells.

Authors:  Misa Gokyu; Hiroaki Kobayashi; Hiromi Nanbara; Takeaki Sudo; Yuichi Ikeda; Tomonari Suda; Yuichi Izumi
Journal:  PLoS One       Date:  2014-12-12       Impact factor: 3.240

8.  Mortality and Causes of Death in Patients with Sporadic Inclusion Body Myositis: Survey Study Based on the Clinical Experience of Specialists in Australia, Europe and the USA.

Authors:  Mark A Price; Victoria Barghout; Olivier Benveniste; Lisa Christopher-Stine; Alastair Corbett; Marianne de Visser; David Hilton-Jones; John T Kissel; Thomas E Lloyd; Ingrid E Lundberg; Francis Mastaglia; Tahseen Mozaffar; Merrilee Needham; Jens Schmidt; Kumaraswamy Sivakumar; Carla DeMuro; Brian S Tseng
Journal:  J Neuromuscul Dis       Date:  2016-03-03

Review 9.  Immune and myodegenerative pathomechanisms in inclusion body myositis.

Authors:  Christian W Keller; Jens Schmidt; Jan D Lünemann
Journal:  Ann Clin Transl Neurol       Date:  2017-05-16       Impact factor: 4.511

10.  How citation distortions create unfounded authority: analysis of a citation network.

Authors:  Steven A Greenberg
Journal:  BMJ       Date:  2009-07-20
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