| Literature DB >> 17572510 |
Klemen Strle1, Robert H McCusker, Lynn Tran, Alexandra King, Rodney W Johnson, Gregory G Freund, Robert Dantzer, Keith W Kelley.
Abstract
IL-10 is an anti-inflammatory cytokine that suppresses synthesis of proinflammatory cytokines and their receptors. Here we tested the possibility that TNFalpha-induced hormone resistance in myoblasts might be overcome by IL-10. We found that IL-10 restores myogenesis by suppressing the ability of exogenous TNFalpha to inhibit IGF-I-induced myogenin. This protection occurs without decreasing global activity of TNF receptors since IL-10 does not impair TNFalpha-induced IL-6 synthesis or ERK1/2 phosphorylation. Instead, IL-10 acts to prevent TNFalpha-induced phosphorylation of JNK. These findings demonstrate that IL-10 serves a previously unrecognized protective role in muscle progenitors by overcoming TNFalpha-induced resistance to IGF-I.Entities:
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Year: 2007 PMID： 17572510 PMCID： PMC2078530 DOI： 10.1016/j.jneuroim.2007.05.003
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478