INTRODUCTION: Several neurological complications are associated with cerebral malaria (CM). However, few long-term data from childhood survivors have been published. METHODS: A cross-sectional study was carried out in Mali among children followed from 1999 to 2002 after serious and complicated malaria. Our aim was to evaluate the persistent neurological sequelae associated with CM. RESULTS: This study concerned 101 subjects who had had CM. Mean age was 5.6+/-3.6 years. Twenty-eight children presented persistent neurological sequelae (27.7p.cent). Among them eight (7.9p.cent) children had developed these sequelae just after CM and 20 (19.8p.cent) a few months later: headaches, mental retardation, speech delay, bucco-facial dyspraxia, diplegia and frontal syndrome (one case each), dystonia (two cases), epilepsy (five cases) and behavior and attention disorders (15 cases). CONCLUSIONS: In this study, we show that neurological signs due to CM can persist in the long run. Long-term follow-up and proper management after CM are essential.
INTRODUCTION: Several neurological complications are associated with cerebral malaria (CM). However, few long-term data from childhood survivors have been published. METHODS: A cross-sectional study was carried out in Mali among children followed from 1999 to 2002 after serious and complicated malaria. Our aim was to evaluate the persistent neurological sequelae associated with CM. RESULTS: This study concerned 101 subjects who had had CM. Mean age was 5.6+/-3.6 years. Twenty-eight children presented persistent neurological sequelae (27.7p.cent). Among them eight (7.9p.cent) children had developed these sequelae just after CM and 20 (19.8p.cent) a few months later: headaches, mental retardation, speech delay, bucco-facial dyspraxia, diplegia and frontal syndrome (one case each), dystonia (two cases), epilepsy (five cases) and behavior and attention disorders (15 cases). CONCLUSIONS: In this study, we show that neurological signs due to CM can persist in the long run. Long-term follow-up and proper management after CM are essential.
Authors: Vidhan Jain; Avinash C Nagpal; Pradeep K Joel; Manmohan Shukla; Mrigendra P Singh; Rasik B Gupta; Aditya P Dash; Saroj K Mishra; Venkatachalam Udhayakumar; Jonathan K Stiles; Neeru Singh Journal: Am J Trop Med Hyg Date: 2008-10 Impact factor: 2.345
Authors: Gretchen L Birbeck; Malcolm E Molyneux; Peter W Kaplan; Karl B Seydel; Yamikani F Chimalizeni; Kondwani Kawaza; Terrie E Taylor Journal: Lancet Neurol Date: 2010-11-04 Impact factor: 44.182
Authors: Penelope A Phillips-Howard; Frank O Odhiambo; Mary Hamel; Kubaje Adazu; Marta Ackers; Anne M van Eijk; Vincent Orimba; Anja van't Hoog; Caryl Beynon; John Vulule; Mark A Bellis; Laurence Slutsker; Kevin deCock; Robert Breiman; Kayla F Laserson Journal: PLoS One Date: 2012-11-05 Impact factor: 3.240