BACKGROUND/AIMS: Different neuroimaging techniques have indicated that auditory association and language cortices are active in patients with schizophrenia and auditory hallucinations. Auditory verbal hallucinations are thought to arise from a disorder of inner speech, but little is known about their origin. METHODS: Spontaneous magnetoencephalographic (MEG) measurements were recorded with a 74-channel two-sensor system (BIOMAGNES II) in 16 patients with schizophrenia and 8 healthy subjects in frequency ranges from 2 to 6 and 12.5 to 30 Hz. Eight patients had auditory hallucinations during the MEG recordings. RESULTS: The total group of patients with schizophrenia showed a statistically significant elevation of the number of dipoles and dipole density maxima in slow frequency ranges compared to healthy subjects (p <0.001). Significant dipole activities in the fast frequency range were only found during auditory hallucinations (p <0.001). Dipole localization was concentrated in frontal and temporal regions depending on different qualities of hallucinations. In patients with external imperative voices we found a parallel activation of the dorsolateral frontal and temporal cortex. CONCLUSION: We conclude that various auditory hallucinations in schizophrenia are induced by different neuronal activities and may be represented by different cortical regions.
BACKGROUND/AIMS: Different neuroimaging techniques have indicated that auditory association and language cortices are active in patients with schizophrenia and auditory hallucinations. Auditory verbal hallucinations are thought to arise from a disorder of inner speech, but little is known about their origin. METHODS: Spontaneous magnetoencephalographic (MEG) measurements were recorded with a 74-channel two-sensor system (BIOMAGNES II) in 16 patients with schizophrenia and 8 healthy subjects in frequency ranges from 2 to 6 and 12.5 to 30 Hz. Eight patients had auditory hallucinations during the MEG recordings. RESULTS: The total group of patients with schizophrenia showed a statistically significant elevation of the number of dipoles and dipole density maxima in slow frequency ranges compared to healthy subjects (p <0.001). Significant dipole activities in the fast frequency range were only found during auditory hallucinations (p <0.001). Dipole localization was concentrated in frontal and temporal regions depending on different qualities of hallucinations. In patients with external imperative voices we found a parallel activation of the dorsolateral frontal and temporal cortex. CONCLUSION: We conclude that various auditory hallucinations in schizophrenia are induced by different neuronal activities and may be represented by different cortical regions.
Authors: Judith M Ford; Thomas Dierks; Derek J Fisher; Christoph S Herrmann; Daniela Hubl; Jochen Kindler; Thomas Koenig; Daniel H Mathalon; Kevin M Spencer; Werner Strik; Remko van Lutterveld Journal: Schizophr Bull Date: 2012-02-23 Impact factor: 9.306
Authors: Juliann M Mellin; Sankaraleengam Alagapan; Caroline Lustenberger; Courtney E Lugo; Morgan L Alexander; John H Gilmore; L Fredrik Jarskog; Flavio Fröhlich Journal: Eur Psychiatry Date: 2018-03-11 Impact factor: 5.361
Authors: M P Kelly; J M Stein; C G Vecsey; C Favilla; X Yang; S F Bizily; M F Esposito; G Wand; S J Kanes; T Abel Journal: Mol Psychiatry Date: 2008-11-25 Impact factor: 15.992
Authors: Remko van Lutterveld; Arjan Hillebrand; Kelly M J Diederen; Kirstin Daalman; René S Kahn; Cornelis J Stam; Iris E C Sommer Journal: PLoS One Date: 2012-07-23 Impact factor: 3.240