| Literature DB >> 17570666 |
John I Trujillo1, Marvin J Meyers, David R Anderson, Shridhar Hegde, Matthew W Mahoney, William F Vernier, Ingrid P Buchler, Kun K Wu, Syaulan Yang, Syaluan Yang, Susan J Hartmann, David B Reitz.
Abstract
A structure-activity relationship study was conducted on a series of tetrahydro-beta-carboline-1-carboxylic acid analogs in order to identify the key functionality responsible for activity against the mitogen-activated protein kinase-activated protein kinase 2 enzyme (MK-2). The compounds were further evaluated for their ability to inhibit TNFalpha production in U937 cells and in vivo. These compounds represent a novel structural class of compounds capable of inhibiting MK-2 with remarkable selectivity.Entities:
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Year: 2007 PMID： 17570666 DOI： 10.1016/j.bmcl.2007.05.070
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823