Literature DB >> 17570314

Genetic disorders and congenital malformations in pediatric long-term care.

Meghan O'Malley1, R Gordon Hutcheon.   

Abstract

OBJECTIVE: The objective of this study was to gain insight into the contribution of genetic disorders and congenital malformations to residents of a pediatric long-term care and rehabilitation center.
DESIGN: Record review.
SETTING: The setting was a 136-bed long-term care and rehabilitation center in New York City. PARTICIPANTS: Participants were residents who spent 1 day or longer as in-patients at the center over a 1-year period of time. MEASUREMENTS: Resident diagnoses were categorized as problems with known genetic basis, problems with presumed genetic basis, acquired disorders with genetic predisposition, contiguous gene syndromes, multiple congenital anomalies, prematurity, cerebral palsy, hypoxic ischemic encephalopathy, conditions with unknown etiology, and defined conditions without genetic basis. The percentage of individuals with genetic disorders and/or congenital malformations was determined.
RESULTS: Genetic disorders and congenital anomalies were responsible for 50% of overall admissions and 60% of end-of-life care admissions to a pediatric long-term care center.
CONCLUSION: An understanding of the contribution of genetic disorders and congenital malformations can assist long-term care administrators as they plan for the needs of their future residents.

Entities:  

Mesh:

Year:  2007        PMID: 17570314     DOI: 10.1016/j.jamda.2007.02.008

Source DB:  PubMed          Journal:  J Am Med Dir Assoc        ISSN: 1525-8610            Impact factor:   4.669


  11 in total

1.  Whole-genome sequencing for identification of Mendelian disorders in critically ill infants: a retrospective analysis of diagnostic and clinical findings.

Authors:  Laurel K Willig; Josh E Petrikin; Laurie D Smith; Carol J Saunders; Isabelle Thiffault; Neil A Miller; Sarah E Soden; Julie A Cakici; Suzanne M Herd; Greyson Twist; Aaron Noll; Mitchell Creed; Patria M Alba; Shannon L Carpenter; Mark A Clements; Ryan T Fischer; J Allyson Hays; Howard Kilbride; Ryan J McDonough; Jamie L Rosterman; Sarah L Tsai; Lee Zellmer; Emily G Farrow; Stephen F Kingsmore
Journal:  Lancet Respir Med       Date:  2015-04-27       Impact factor: 30.700

2.  Frequency of genetic diseases and health coverage of children requiring admission in a general pediatric clinic of northern Greece.

Authors:  Theodoros Lialiaris; Elpis Mantadakis; Dimitra Kareli; Panagiotis Mpountoukas; Aggelos Tsalkidis; Athanassios Chatzimichail
Journal:  Ital J Pediatr       Date:  2010-01-26       Impact factor: 2.638

Review 3.  When to suspect a genetic syndrome.

Authors:  Benjamin D Solomon; Maximilian Muenke
Journal:  Am Fam Physician       Date:  2012-11-01       Impact factor: 3.292

4.  Associations Between Enteral Nutrition and Acute Respiratory Infection Among Patients in New York Metropolitan Region Pediatric Long-Term Care Facilities.

Authors:  Marissa Burgermaster; Meghan Murray; Lisa Saiman; David S Seres; Elaine L Larson
Journal:  Nutr Clin Pract       Date:  2018-02-15       Impact factor: 3.080

5.  Rapid Whole Genome Sequencing Has Clinical Utility in Children in the PICU.

Authors:  Erica F Sanford; Michelle M Clark; Lauge Farnaes; Matthew R Williams; James C Perry; Elizabeth G Ingulli; Nathaly M Sweeney; Ami Doshi; Jeffrey J Gold; Benjamin Briggs; Matthew N Bainbridge; Michele Feddock; Kelly Watkins; Shimul Chowdhury; Shareef A Nahas; David P Dimmock; Stephen F Kingsmore; Nicole G Coufal
Journal:  Pediatr Crit Care Med       Date:  2019-11       Impact factor: 3.624

6.  Genetics and pediatric hospital admissions, 1985 to 2017.

Authors:  Stephanie Gjorgioski; Jane Halliday; Merilyn Riley; David J Amor; Martin B Delatycki; Agnes Bankier
Journal:  Genet Med       Date:  2020-06-19       Impact factor: 8.822

7.  The NSIGHT1-randomized controlled trial: rapid whole-genome sequencing for accelerated etiologic diagnosis in critically ill infants.

Authors:  Josh E Petrikin; Julie A Cakici; Michelle M Clark; Laurel K Willig; Nathaly M Sweeney; Emily G Farrow; Carol J Saunders; Isabelle Thiffault; Neil A Miller; Lee Zellmer; Suzanne M Herd; Anne M Holmes; Serge Batalov; Narayanan Veeraraghavan; Laurie D Smith; David P Dimmock; J Steven Leeder; Stephen F Kingsmore
Journal:  NPJ Genom Med       Date:  2018-02-09       Impact factor: 8.617

8.  Who receives home-based perinatal palliative care: experience from Poland.

Authors:  Aleksandra Korzeniewska-Eksterowicz; Łukasz Przysło; Bogna Kędzierska; Małgorzata Stolarska; Wojciech Młynarski
Journal:  Biomed Res Int       Date:  2013-09-03       Impact factor: 3.411

9.  Rapid whole-genome sequencing decreases infant morbidity and cost of hospitalization.

Authors:  Lauge Farnaes; Amber Hildreth; Nathaly M Sweeney; Michelle M Clark; Shimul Chowdhury; Shareef Nahas; Julie A Cakici; Wendy Benson; Robert H Kaplan; Richard Kronick; Matthew N Bainbridge; Jennifer Friedman; Jeffrey J Gold; Yan Ding; Narayanan Veeraraghavan; David Dimmock; Stephen F Kingsmore
Journal:  NPJ Genom Med       Date:  2018-04-04       Impact factor: 8.617

10.  Meta-analysis of the diagnostic and clinical utility of genome and exome sequencing and chromosomal microarray in children with suspected genetic diseases.

Authors:  Michelle M Clark; Zornitza Stark; Lauge Farnaes; Tiong Y Tan; Susan M White; David Dimmock; Stephen F Kingsmore
Journal:  NPJ Genom Med       Date:  2018-07-09       Impact factor: 8.617

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