Raúl A Bastarrachea1, Jack Kent, Anthony G Comuzzie. 1. Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, Estados Unidos. raulbs@darwin.sfbr.org
Abstract
BACKGROUND AND OBJECTIVE: The aims of the GEMM Family Study are to clarify the genetic determinants of cardiovascular disease (CVD) risk in individuals born and living in Mexico. The authors evaluate the heritabilities (h2) of CVD risk factors in Mexicans from a preliminary cohort already studied. Heritabilities for CVD risk factor phenotypes are estimated using a variance component approach. SUBJECTS AND METHOD: As a first step in implementing a large, multi-center collaborative study, we recruited 381 individuals in 21 families at 8 regions across Mexico. Anthropometric and fasting blood samples were collected from all participants. We estimated the magnitude of the random effects of shared genes (heritability) using the genetic software SOLAR. RESULTS: We found significant heritability for phenotypes including waist circumference (0.28 [0.12]), plasma glucose (0.14 [0.08]), body mass index (BMI) (0.28 [0.10]), systolic blood pressure (BP) (0.13 [0.06]), serum cholesterol (0.31 [0.13]) and serum triglyceride (0.23 [0.10]). CONCLUSIONS: These preliminary data represent the first heritability estimates for these phenotypes in Mexico. The results indicate that this study design offers excellent power for gene discovery relative to metabolic disease.
BACKGROUND AND OBJECTIVE: The aims of the GEMM Family Study are to clarify the genetic determinants of cardiovascular disease (CVD) risk in individuals born and living in Mexico. The authors evaluate the heritabilities (h2) of CVD risk factors in Mexicans from a preliminary cohort already studied. Heritabilities for CVD risk factor phenotypes are estimated using a variance component approach. SUBJECTS AND METHOD: As a first step in implementing a large, multi-center collaborative study, we recruited 381 individuals in 21 families at 8 regions across Mexico. Anthropometric and fasting blood samples were collected from all participants. We estimated the magnitude of the random effects of shared genes (heritability) using the genetic software SOLAR. RESULTS: We found significant heritability for phenotypes including waist circumference (0.28 [0.12]), plasma glucose (0.14 [0.08]), body mass index (BMI) (0.28 [0.10]), systolic blood pressure (BP) (0.13 [0.06]), serum cholesterol (0.31 [0.13]) and serum triglyceride (0.23 [0.10]). CONCLUSIONS: These preliminary data represent the first heritability estimates for these phenotypes in Mexico. The results indicate that this study design offers excellent power for gene discovery relative to metabolic disease.
Authors: Hugo Villamil-Ramírez; Paola León-Mimila; Luis R Macias-Kauffer; Adrián Canizalez-Román; Marisela Villalobos-Comparán; Nidia León-Sicairos; Joel Vega-Badillo; Fausto Sánchez-Muñoz; Blanca López-Contreras; Sofía Morán-Ramos; Teresa Villarreal-Molina; Luis C Zurita; Francisco Campos-Pérez; Adriana Huertas-Vazquez; Rafael Bojalil; Sandra Romero-Hidalgo; Carlos A Aguilar-Salinas; Samuel Canizales-Quinteros Journal: J Hum Genet Date: 2016-11-24 Impact factor: 3.172
Authors: Raúl A Bastarrachea; Esther C Gallegos-Cabriales; Edna J Nava-González; Karin Haack; V Saroja Voruganti; Jac Charlesworth; Hugo A Laviada-Molina; Rosa A Veloz-Garza; Velia Margarita Cardenas-Villarreal; Salvador B Valdovinos-Chavez; Patricia Gomez-Aguilar; Guillermo Meléndez; Juan Carlos López-Alvarenga; Harald H H Göring; Shelley A Cole; John Blangero; Anthony G Comuzzie; Jack W Kent Journal: Adv Nutr Date: 2012-07-01 Impact factor: 8.701
Authors: Manju Mamtani; Hemant Kulkarni; Thomas D Dyer; Laura Almasy; Michael C Mahaney; Ravindranath Duggirala; Anthony G Comuzzie; John Blangero; Joanne E Curran Journal: PLoS One Date: 2013-03-11 Impact factor: 3.240
Authors: Manju Mamtani; Peter J Meikle; Hemant Kulkarni; Jacquelyn M Weir; Christopher K Barlow; Jeremy B Jowett; Claire Bellis; Thomas D Dyer; Laura Almasy; Michael C Mahaney; Ravindranath Duggirala; Anthony G Comuzzie; John Blangero; Joanne E Curran Journal: Obesity (Silver Spring) Date: 2013-09-20 Impact factor: 5.002